Evidence map›Paper›PMID 38807535›Full record

ArticleOccupational medicine (Oxford, England)2024

Cardiovascular and lifestyle risk factors of mild cognitive impairment in UK veterans and non-veterans.

R Akhanemhe, S A M Stevelink, A Corbett, C Ballard, H Brooker, B Creese, Dag Aarsland, Adam Hampshire, Neil Greenberg

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Article in Occupational medicine (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

R AkhanemheKing's Centre for Military Health Research, Department of Psychological Medicine, Institute for Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-4729-2269
S A M StevelinkKing's Centre for Military Health Research, Department of Psychological Medicine, Institute for Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-7655-7986
A CorbettExeter University Medical School, University of Exeter, Exeter, UK.
C BallardExeter University Medical School, University of Exeter, Exeter, UK.ORCID 0000-0003-0022-5632
H BrookerExeter University Medical School, University of Exeter, Exeter, UK.
B CreeseDivision of Psychology, Department of Life Sciences, Brunel University London, London, UK.
Dag AarslandDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Adam HampshireDepartment of Medicine, Imperial College London, London, UK.ORCID 0000-0002-5176-5420
Neil GreenbergKing's Centre for Military Health Research, Department of Psychological Medicine, Institute for Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-4550-2971

Funding

Alzheimer's Research UK South West NetworkAlzheimer's Society AS-PhD-18b-002Care Research Exeter Biomedical Research CentreNational Institute of Health
6 · The paper itself

Abstract

backgroundThe link between poor cardiovascular health (CVH), lifestyle and mild cognitive impairment (MCI) has been well established in the general population. However, there is limited research exploring these associations in ageing UK veterans.

aimsThis study explored the risk of MCI and its association with nine CVH and lifestyle risk factors (including diabetes, heart disease, high cholesterol, high blood pressure, obesity, stroke, physical inactivity, the frequency of alcohol consumption and smoking) in UK veterans and non-veterans.

methodsThis prospective cohort study comprised data from the PROTECT study between 2014 and 2022. Participants comprised of UK military veterans and non-veterans aged ≥50 years at baseline. Veteran status was defined using the Military Service History Questionnaire. CVH and lifestyle risk factors were defined using a combination of self-report measures, medication history or physical measurements. MCI was defined as the presence of subjective and objective cognitive impairment.

resultsBased on a sample of 9378 veterans (n = 488) and non-veterans (n = 8890), the findings showed the risk of MCI significantly reduced in veterans with obesity, those who frequently consumed alcohol and were physically inactive compared to non-veterans. The risk of MCI significantly increased in veterans with diabetes (hazards ratio [HR] = 2.22, 95% confidence interval [CI] 1.04-4.75, P ≤ 0.05) or high cholesterol (HR = 3.11, 95% CI 1.64-5.87, P ≤ 0.05) compared to veterans without.

conclusionsThis study identified CVH and lifestyle factors of MCI in UK veterans and non-veterans. Further work is needed to understand these associations and the underpinning mechanisms which could determine intervention strategies to reduce the risk of MCI.

Indexed as

Cardiovascular DiseasesCognitive DysfunctionLife StyleVeteransAgedCohort StudiesFemaleHumansMaleMiddle AgedObesityProspective StudiesRisk FactorsUnited Kingdom

Identifiers

PMID38807535
PMCPMC11165370

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