ArticleThe Journal of cell biology1985
Giant axonal neuropathy: a conditional mutation affecting cytoskeletal organization.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer's Disease and Phytochemicals-Based Interventions.Molecular neurobiology · 2024Review
- E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy.Frontiers in physiology · 2020Review
- Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins.F1000Research · 2019Review
- Giant axonal neuropathy: a rare inherited neuropathy with simple clinical clues.BMJ case reports · 2014Article
- Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation.The Journal of clinical investigation · 2013Article
- Explaining intermediate filament accumulation in giant axonal neuropathy.Rare diseases (Austin, Tex.) · 2013Article
- Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton.Journal of virology · 2009Article
- Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway.Human molecular genetics · 2009Article
- Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients.BMC genetics · 2007Article
- Formation of GFAP cytoplasmic inclusions in astrocytes and their disaggregation by alphaB-crystallin.The American journal of pathology · 1999Article
- Transgenic mice in the study of ALS: the role of neurofilaments.Brain pathology (Zurich, Switzerland) · 1998Review
- Intermediate filaments as dynamic structures.Cancer metastasis reviews · 1996Review
- Giant axonal neuropathy (GAN): an immunohistochemical and ultrastructural study report of a Latin American case.Acta neuropathologica · 1990Article
- Abnormal organization of keratin intermediate filaments in cultured keratinocytes of epidermolysis bullosa simplex.Archives of dermatological research · 1989Article
- Giant axonal neuropathy. A neuropathological study.Acta neuropathologica · 1987Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant axonal neuropathy (GAN) results from autosomal recessive mutations (gan-) that affect cytoskeletal organization; specifically, intermediate filaments (IFs) are found collapsed into massive bundles in a variety of different cell types. We studied the gan- fibroblast lines WG321 and WG139 derived from different GAN patients. Although previous studies implied that the gan- IF phenotype was constitutive, we find that it is conditional. That is, when cells were grown under the permissive condition of medium containing over 2% fetal calf serum, most cells had normal IF organization. IF bundles formed when gan- cells were transferred to the nonpermissive condition of low (0.1%) serum. Microtubule organization appeared normal in the presence or absence of serum. The effect of serum starvation was largely blocked or reversed by the addition of BSA to the culture media. We found no evidence that the gan- phenotype depends upon progress through the cell cycle. We discuss the possible role of serum effects in the etiology of GAN and speculate as to the molecular nature of the gan- defect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.