Evidence map›Paper›PMID 38807069›Full record

ArticleBMC pregnancy and childbirth2024

Perinatal outcomes and growth discordance of triplet pregnancies based on chorionicity: a retrospective cohort study.

Qing Hu, Zhaomin Zeng, Hongyan Liu, Hua Liao, Tingting Xu, Haiyan Yu

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PubMed Full text at PMC Publisher
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Article in BMC pregnancy and childbirth, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Qing HuDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Zhaomin ZengDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Hongyan LiuDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Hua LiaoDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Tingting XuDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China.
Haiyan YuDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3 Section, South Renmin Road, Chengdu, Sichuan, 610041, China. fanjy422@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe worldwide occurrence of triplet pregnancy is estimated to be 0.093%, with a natural incidence of approximately 1 in 8000. This study aims to analyze the neonatal health status and birth weight discordance (BWD) of triplets based on chorionicity from birth until discharge.

methodsThis was a retrospective study. We reviewed a total of 136 triplet pregnancies at our tertiary hospital between January 1, 2001, and December 31, 2021. Maternal and neonatal outcomes, inter-triplet BWD, neonatal morbidity, and mortality were analyzed.

resultsAmong all cases, the rates of intrauterine death, neonatal death, and perinatal death were 10.29, 13.07, and 24.26%, respectively. Thirty-seven of the cases resulted in fetal loss, including 13 with fetal anomalies. The maternal complications and neonatal outcomes of the 99 triplet pregnancies without fetal loss were compared across different chorionicities, including a dichorionic (DC) group (41 cases), trichorionic (TC) group (37 cases), and monochorionic (MC) group (21 cases). Neonatal hypoproteinemia (P < 0.001), hyperbilirubinemia (P < 0.019), and anemia (P < 0.003) exhibited significant differences according to chorionicity, as did the distribution of BWD (P < 0.001). More than half of the cases in the DC and TC groups had a BWD < 15%, while those in the MC group had a BWD < 50% (47.6%). TC pregnancy decreased the risk of neonatal anemia (adjusted odds ratio [AOR] = 0.084) and need for blood transfusion therapy after birth (AOR = 0.119). In contrast, a BWD > 25% increased the risk of neonatal anemia (AOR = 10.135) and need for blood transfusion after birth (AOR = 7.127). TC pregnancy, MCDA or MCTA, and BWD > 25% increased neonatal hypoproteinemia, with AORs of 4.629, 5.123, and 5.343, respectively.

conclusionsThe BWD differed significantly according to chorionicity. Additionally, TC pregnancies reduced the risk of neonatal anemia and need for blood transfusion, but increased the risk of neonatal hypoproteinemia. In contrast, the BWD between the largest and smallest triplets increased the risk of neonatal anemia and the need for blood transfusion. TC pregnancy, MCDA or MCTA, and BWD > 25% increased the risks of neonatal hypoproteinemia. However, due to the limited number of triplet pregnancies, further exploration of the underlying mechanism is warranted.

Indexed as

ChorionPregnancy OutcomePregnancy, TripletAdultBirth WeightFemaleFetal DeathHumansInfant, NewbornPregnancyRetrospective StudiesTripletsBirth weight discordanceDichorionic tripletsMonochorionic tripletsPerinatal outcomesTrichorionic tripletsTriplet pregnancy

Identifiers

PMID38807069
PMCPMC11131281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.