Evidence map›Paper›PMID 38807052›Full record

ArticleBMC infectious diseases2024

Vertical transmission of SARS-CoV-2 delta-variant in a preterm infant.

Muhammad T K Zia, Kishan Kumar, Edmund La Gamma, Fauzia Shakeel, Iman Hanna, Xinhua Lin, Nazeeh Hanna

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muhammad T K ZiaDepartment of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Kishan KumarDepartment of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Edmund La GammaDepartment of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Fauzia ShakeelDepartment of Pediatrics, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Iman HannaDepartment of Pathology, NYU Langone Hospital-Long Island, New York University Grossman Long Island School of Medicine, Mineola, NY, USA.
Xinhua LinDivision of Neonatology, Department of Pediatrics, NYU Langone Hospital-Long Island, New York University Grossman Long Island School of Medicine, 259 First Street, Mineola, NY, 11501, USA.
Nazeeh HannaDivision of Neonatology, Department of Pediatrics, NYU Langone Hospital-Long Island, New York University Grossman Long Island School of Medicine, 259 First Street, Mineola, NY, 11501, USA. nazeehhanna@gmail.com.

Funding

Placenta-specific miR-519c-mediated induction of immune tolerance in human placentaR01HD098258 · NICHD · NYU LONG ISLAND SCHOOL OF MEDICINE · PI HANNA, NAZEEH N · 2020 to 2024
$1.8M
National Institute of Child Health and Human Development NIH 1R01HD098258NICHD NIH HHS R01 HD098258
6 · The paper itself

Abstract

backgroundAs SARS-CoV-2 continues to be relevant and cause illnesses, the effect of emerging virus variants on perinatal health remains to be elucidated. It was demonstrated that vertical transmission of SARS-CoV-2 is a relatively rare event in the original SARS-CoV-2 strain. However, very few reports describe vertical transmission related to the delta-variant. CASE PRESENTATION: We report a case of a preterm male neonate born to a mother with positive SARS-CoV-2 and mild respiratory complications. The neonate was born by cesarean section due to fetal distress. The rupture of the amniotic membrane was at delivery. The neonate had expected prematurity-related complications. His nasopharyngeal swabs for RT-PCR were positive from birth till three weeks of age. RT-ddPCR of the Placenta showed a high load of the SARS-CoV-2 virus with subgenomic viral RNA. RNAscope technique demonstrated both the positive strand of the S gene and the orf1ab negative strand. Detection of subgenomic RNA and the orf1ab negative strand indicats active viral replication in the placenta.

conclusionsOur report demonstrates active viral replication of the SARS-CoV-2 delta-variant in the placenta associated with vertical transmission in a preterm infant.

Indexed as

COVID-19Infant, PrematureInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousSARS-CoV-2AdultCesarean SectionFemaleHumansInfant, NewbornMalePlacentaPregnancyRNA, ViralRNA, ViralCOVID-19Delta variantPreterm infantSARS-CoV-2Vertical transmission

Identifiers

PMID38807052
PMCPMC11134764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.