Evidence map›Paper›PMID 38807038›Full record

ArticleBMC infectious diseases2024

Immunogenicity evaluation of primary polio vaccination schedule with inactivated poliovirus vaccines and bivalent oral poliovirus vaccine.

Jiawei Xu, Yang Liu, Wei Qiu, Wenwen Li, Xiaoxiao Hu, Xia Li, Qiang Fan, Wenge Tang, Yujie Wang, Qing Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiawei Xu *EPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China.
Yang Liu *EPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China.
Wei QiuEPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China.
Wenwen LiEPI Department, Hechuan District Center Disease Control and Prevention, Chongqing, China.
Xiaoxiao HuEPI Department, Liangping District Center Disease Control and Prevention, Chongqing, China.
Xia LiEPI Department, Rongchang District Center Disease Control and Prevention, Chongqing, China.
Qiang FanEPI Department, Zhongxian County Center Disease Control and Prevention, Chongqing, China.
Wenge TangEPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China.
Yujie WangSchool of Public Health, Chongqing Medical University, Chongqing, China.
Qing WangEPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China. 576801380@qq.com.
Ning YaoEPI Department, Chongqing Municipal Center for Disease Control and Prevention, No.8 Changjiang 2nd Street, Yuzhong District, Chongqing, 400042, China. yaoningaa@outlook.com.

Funding

Chongqing Health Commission and Chongqing Science and Technology Commission 2020FYYX040
6 · The paper itself

Abstract

backgroundTo assess the immunogenicity of the current primary polio vaccination schedule in China and compare it with alternative schedules using Sabin or Salk-strain IPV (sIPV, wIPV).

methodsA cross-sectional investigation was conducted at four sites in Chongqing, China, healthy infants aged 60-89 days were conveniently recruited and divided into four groups according to their received primary polio vaccination schedules (2sIPV + bOPV, 2wIPV + bOPV, 3sIPV, and 3wIPV). The sero-protection and neutralizing antibody titers against poliovirus serotypes (type 1, 2, and 3) were compared after the last dose.

resultsThere were 408 infants completed the protocol. The observed seropositivity was more than 96% against poliovirus types 1, 2, and 3 in all groups. IPV-only groups induced higher antibody titers(GMT) against poliovirus type 2 (Median:192, QR: 96-384, P<0.05) than the "2IPV + bOPV" group. While the "2IPV + bOPV" group induced significantly higher antibody titers against poliovirus type 1 (Median:2048, QR: 768-2048, P<0.05)and type 3 (Median:2048, QR: 512-2048, P<0.05) than the IPV-only group.

conclusionsOur findings have proved that the two doses of IPV with one dose of bOPV is currently the best polio routine immunization schedule in China.

Indexed as

Antibodies, NeutralizingAntibodies, ViralImmunization SchedulePoliomyelitisPoliovirusPoliovirus Vaccine, InactivatedPoliovirus Vaccine, OralChinaCross-Sectional StudiesFemaleHumansImmunogenicity, VaccineInfantMaleVaccinationAntibodies, NeutralizingAntibodies, ViralPoliovirus Vaccine, InactivatedPoliovirus Vaccine, OralbOPVImmunogenicityIPVSequential immunization

Identifiers

PMID38807038
PMCPMC11131326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.