Evidence map›Paper›PMID 38806882›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Efficacy of a dual task protocol on neurophysiological and clinical outcomes in migraine: a randomized control trial.

Manuela Deodato, Antonio Granato, Alex Buoite Stella, Miriam Martini, Enrico Marchetti, Ilaria Lise, Alessandra Galmonte, Luigi Murena, Paolo Manganotti

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manuela DeodatoDepartment of Life Sciences, University of Trieste, Trieste, Italy. mdeodato@units.it.ORCID http://orcid.org/0000-0002-6150-6887
Antonio GranatoDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Alex Buoite StellaDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Miriam MartiniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Enrico MarchettiDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Ilaria LiseDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Alessandra GalmonteDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Luigi MurenaDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Paolo ManganottiDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main aim of this study was to investigate the efficacy of a dual task protocol in people with episodic migraine with respect to both active exercises only and cognitive task only treatments, concerning some neurophysiological and clinical outcomes. A randomized control trial was adopted in people with episodic migraine without aura. Some neurophysiological and clinical outcomes were collected (t0): resting motor threshold (rMT), short intracortical inhibition (SICI) and facilitation (ICF), pressure pain threshold (PPT), trail making test (TMT), frontal assessment battery (FAB), headache-related disability (MIDAS) and headache parameters. Then, participants were randomized into three groups: active exercise only (n = 10), cognitive task only (n = 10) and dual task protocol (n = 10). After 3 months of each treatment and after 1-month follow-up the same neurophysiological and clinical outcomes were revaluated. A significant time x group effect was only found for the trapezius muscle (p = 0.012, pη2 = 0.210), suggesting that PPT increased significantly only in active exercise and dual task protocol groups. A significant time effect was found for rMT (p < 0.001, pη2 = 0.473), MIDAS (p < 0.001, pη2 = 0.426), TMT (p < 0.001, pη2 = 0.338) and FAB (p < 0.001, pη2 = 0.462). A repeated measures ANOVA for SICI at 3 ms highlighted a statistically significant time effect for the dual task group (p < 0.001, pη2 = 0.629), but not for the active exercises group (p = 0.565, pη2 = 0.061), and for the cognitive training (p = 0.357, pη2 = 0.108). The dual task protocol seems to have a more evident effect on both habituation and sensitization outcomes than the two monotherapies taken alone in people with migraine.

Indexed as

Exercise TherapyMigraine DisordersAdultEvoked Potentials, MotorFemaleFollow-Up StudiesHumansMaleMiddle AgedPain ThresholdTranscranial Magnetic StimulationTreatment OutcomeYoung AdultActive exerciseCognitive trainingDual task protocolEpisodic migraineTranscranial magnetic stimulation

Identifiers

PMID38806882
PMCPMC11255006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.