Evidence map›Paper›PMID 38806718›Full record

ArticleArchives of toxicology2024

Controversy on health-based guidance values for bisphenol A-the need of criteria for studies that serve as a basis for risk assessment.

Marcel Leist, Andrea Buettner, Patrick Diel, Gerhard Eisenbrand, Bernd Epe, Petra Först, Tilman Grune, Dirk Haller, Volker Heinz, Michael Hellwig and 11 more

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marcel LeistDivision for In Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitaetsstrasse 10, 78464, Konstanz, Germany.
Andrea BuettnerChair of Aroma and Smell Research, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestrasse 9, 91054, Erlangen, Germany.
Patrick DielDepartment of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Gerhard Eisenbrand, Kühler Grund 48/1, 69126, Heidelberg, Germany.
Bernd EpeInstitute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128, Mainz, Germany.
Petra FörstFood Process Engineering, TUM School of Life Sciences, Technical University of Munich, Weihenstephaner Berg 1, 85354, Freising, Germany.
Tilman GruneGerman Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Dirk HallerChair of Nutrition and Immunology, Technical University of Munich, Gregor-Mendel-Strasse 2, Freising, Germany.
Volker HeinzDIL German Institute of Food Technology, Professor-von-Klitzing-Strasse 7, 49610, Quakenbrück, Germany.
Michael HellwigChair of Special Food Chemistry, Technical University Dresden, Bergstrasse 66, 01062, Dresden, Germany.
Hans-Ulrich HumpfInstitute of Food Chemistry, Universität Münster, Corrensstrasse 45, 48149, Münster, Germany.
Henry JägerUniversity of Natural Resources and Life Sciences, Gregor-Mendel-Strasse 33, 1180, Vienna, Austria.
Sabine E KullingDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany.
Angela MallyDepartment of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany.
Doris MarkoDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Strasse 38, 1090, Vienna, Austria.
Ute NöthlingsInstitute for Nutrition and Food Science, Rheinische Friedrich-Wilhelms-University Bonn, Fiedrich-Hirzebruch-Allee 7, 53115, Bonn, Germany.
Elke RöhrdanzUnit Reproductive and Genetic Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175, Bonn, Germany.
Joachim SprangerCharité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Stefan ViethsPaul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225, Langen, Germany.
Wim WätjenInstitute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, 06120, Halle (Saale), Germany.
Jan G HengstlerDepartment of Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. hengstler@ifado.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 2006, the responsible regulatory bodies have proposed five health-based guidance values (HBGV) for bisphenol A (BPA) that differ by a factor of 250,000. This range of HBGVs covers a considerable part of the range from highly toxic to relatively non-toxic substances. As such heterogeneity of regulatory opinions is a challenge not only for scientific risk assessment but also for all stakeholders, the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) analyzed the reasons for the current discrepancy and used this example to suggest improvements for the process of HBGV recommendations. A key aspect for deriving a HBGV is the selection of appropriate studies that allow the identification of a point of departure (PoD) for risk assessment. In the case of BPA, the HBGV derived in the 2023 EFSA assessment was based on a study that reported an increase of Th17 cells in mice with a benchmark dose lower bound (BMDL

Indexed as

Benzhydryl CompoundsPhenolsAnimalsBisphenol A CompoundsDose-Response Relationship, DrugGuidelines as TopicHumansMiceRisk AssessmentBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenols

Identifiers

PMID38806718
PMCPMC11169008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.