Evidence map›Paper›PMID 38806710›Full record

ArticleExperimental brain research2024

Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice.

Hanlin Jiang, Yusuke Kimura, Shota Inoue, Changxin Li, Junpei Hatakeyama, Masahiro Wakayama, Daisuke Takamura, Hideki Moriyama

Abstract read
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In one paragraph

Article in Experimental brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanlin JiangDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Yusuke KimuraDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Shota InoueDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Changxin LiDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Junpei HatakeyamaDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Masahiro WakayamaDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Daisuke TakamuraDepartment of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan.
Hideki MoriyamaLife and Medical Sciences Area, Health Sciences Discipline, Kobe University, Tomogaoka 7-10-2, Suma-ku, Kobe, Hyogo, 654-0142, Japan. morihide@harbor.kobe-u.ac.jp.ORCID http://orcid.org/0000-0001-7753-0091

Funding

Japan Society for the Promotion of Science 19H04050
6 · The paper itself

Abstract

Exercise can induce beneficial improvements in cognition. However, the effects of different modes and intensities of exercise have yet to be explored in detail. This study aimed to identify the effects of different exercise modes (aerobic and resistance) and intensities (low and high) on cognitive performance, adult hippocampal neurogenesis and synaptic plasticity in mice. A total of 40 C57BL/6J mice were randomised into 5 groups (n = 8 mice per group): control, low-intensity aerobic exercise, high-intensity aerobic exercise, low-intensity resistance exercise, and high-intensity resistance exercise. The aerobic exercise groups underwent treadmill training, while the resistance exercise groups underwent ladder climbing training. At the end of the exercise period, cognitive performance was assessed by the Y-maze and Barnes maze. In addition, adult hippocampal neurogenesis was evaluated immunohistochemically by 5-bromo-2'-deoxyuridine (BrdU)/ neuronal nuclei (NeuN) co-labeling. The levels of synaptic plasticity-related proteins in the hippocampus, including synaptophysin (SYP) and postsynaptic density protein 95 (PSD-95), were analyzed by western blotting. Our results showed no significant differences in cognitive performance among the groups. However, high-intensity aerobic exercise significantly increased hippocampal adult neurogenesis relative to the control. A trend towards increased adult neurogenesis was observed in the low-intensity aerobic group compared to the control group. No significant changes in synaptic plasticity were observed among all groups. Our results indicate that high-intensity aerobic exercise may be the most potent stimulator of adult hippocampal neurogenesis.

Indexed as

CognitionHippocampusMice, Inbred C57BLNeurogenesisNeuronal PlasticityPhysical Conditioning, AnimalSynaptophysinAnimalsDisks Large Homolog 4 ProteinMaleMaze LearningMiceDisks Large Homolog 4 ProteinDlg4 protein, mouseSynaptophysinAdult neurogenesisAerobic exerciseCognitive functionHippocampusMiceResistance exercise

Identifiers

PMID38806710

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.