Evidence map›Paper›PMID 38806701›Full record

ArticleJournal of neurology2024

Parkinson's disease with hyposmia and dysautonomia: does it represent a distinct subtype?

So Hoon Yoon, Dae Hyuk You, Han Kyu Na, Sungwoo Kang, Kyoungwon Baik, Mincheol Park, Chul Hyoung Lyoo, Young H Sohn, Phil Hyu Lee

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

So Hoon YoonDepartment of Neurology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, South Korea.
Dae Hyuk YouCollege of Letters and Science, University of Wisconsin-Madison, Madison, WI, USA.
Han Kyu NaDepartment of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Sungwoo KangDepartment of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Kyoungwon BaikDepartment of Neurology, Anam Hospital, Korea University College of Medicine, Seoul, South Korea.
Mincheol ParkDepartment of Neurology, Gwangmyeong Hospital, Chung-Ang University College of Medicine and Graduate School of Medicine, Gwangmyeong, South Korea.
Chul Hyoung LyooDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Young H SohnDepartment of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Phil Hyu LeeDepartment of Neurology, Yonsei University College of Medicine, Seoul, South Korea. phlee@yuhs.ac.ORCID http://orcid.org/0000-0001-9931-8462

Funding

Ministry of Health & Welfare, Republic of Korea HU21C0053
6 · The paper itself

Abstract

background and purposeOlfactory dysfunction or dysautonomia is one of the earliest prodromal nonmotor symptoms of Parkinson's disease (PD). We aimed to investigate whether PD patients with dysautonomia and hyposmia at the de novo stage present different prognoses regarding PD dementia (PDD) conversion, motor complication development, and change in levodopa-equivalent doses (LED).

methodsIn this retrograde cohort study, we included 105 patients with newly diagnosed PD patients who underwent cross-cultural smell identification test (CC-SIT), autonomic function tests (AFT), and dopamine transporter (DAT) scan at the de novo stage. PD patients were divided into Hyposmia + /Dysautonomia + (H + /D +) and Hyposmia - /Dysautonomia - (H - /D -) groups depending on the result of AFT and CC-SIT. Baseline clinical, cognitive, imaging characteristics, longitudinal risks of PDD development and motor complication occurrence, and longitudinal LED changes were compared between the two groups.

resultsWhen compared with the H - /D - group, the H + /D + group showed lower standardized uptake value ratios in all subregions, lower asymmetry index, and steeper ventral - dorsal gradient in the DAT scan. The H + /D + group exhibited poorer performance in frontal/executive function and a higher risk of PDD development. The risk of motor complications including levodopa-induced dyskinesia, wearing off, and freezing of gait, was comparable between the two groups. The analysis of longitudinal changes in LED using a linear mixed model showed that the increase of LED in the H + /D + group was more rapid.

conclusionsOur results suggest that PD patients with dysautonomia and hyposmia at the de novo stage show a higher risk of PD dementia conversion and rapid progression of motor symptoms.

Indexed as

AnosmiaParkinson DiseasePrimary DysautonomiasAgedCohort StudiesDopamine Plasma Membrane Transport ProteinsFemaleHumansLevodopaMaleMiddle AgedDopamine Plasma Membrane Transport ProteinsLevodopaBody-firstBrain-firstDysautonomiaHyposmiaParkinson’s disease

Identifiers

PMID38806701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.