Evidence map›Paper›PMID 38806677›Full record

ArticleCommunications biology2024

Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish.

Shaohong Lai, Hiroshi Shiraishi, Wulan Apridita Sebastian, Nobuyuki Shimizu, Ryohei Umeda, Mayo Ikeuchi, Kyoko Kiyota, Takashi Takeno, Shuya Miyazaki, Shinji Yano and 4 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shaohong Lai *Department of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Hiroshi Shiraishi *Department of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Wulan Apridita SebastianDepartment of Pediatrics, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Nobuyuki ShimizuDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.ORCID 0000-0002-8100-0330
Ryohei UmedaDepartment of Neurophysiology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Mayo IkeuchiDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Kyoko KiyotaDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Takashi TakenoDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Shuya MiyazakiDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Shinji YanoInstitute for Research Management, Oita University, Yufu, Oita, Japan.
Tatsuo ShimadaOita Medical Technology School, Japan College of Judo-Therapy, Acupuncture & Moxibustion Therapy, Oita, Japan.
Akihiko YoshimuraDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Reiko HanadaDepartment of Neurophysiology, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Toshikatsu HanadaDepartment of Cell Biology, Oita University Faculty of Medicine, Yufu, Oita, Japan. thanada@oita-u.ac.jp.ORCID 0000-0002-3317-6366

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 20H03644MEXT | Japan Society for the Promotion of Science (JSPS) 21K06871
6 · The paper itself

Abstract

SMG9 is an essential component of the nonsense-mediated mRNA decay (NMD) machinery, a quality control mechanism that selectively degrades aberrant transcripts. Mutations in SMG9 are associated with heart and brain malformation syndrome (HBMS). However, the molecular mechanism underlying HBMS remains unclear. We generated smg9 mutant zebrafish (smg9

Indexed as

Aging, PrematureNonsense Mediated mRNA DecayZebrafishZebrafish ProteinsAnimalsIntracellular Signaling Peptides and ProteinsMutationOxidative StressRNA, MessengerIntracellular Signaling Peptides and ProteinsRNA, Messengersmg9 protein, zebrafishZebrafish Proteins

Identifiers

PMID38806677
PMCPMC11133409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.