ArticleCommunications biology2024
Neural correlates of obesity across the lifespan.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Network-Level Convergence of Adiposity-Related Gray Matter Alterations: A Coordinate-Based Connectome Mapping Meta-Analysis With Imaging Transcriptomics.Human brain mapping · 2026Pooled it
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents.medRxiv : the preprint server for health sciences · 2026Article
- Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health.Actas espanolas de psiquiatria · 2026Article
- Inter-individual variability of neurotransmitter receptor and transporter density in the human brain.Brain structure & function · 2026Article
- Prefrontal Structural Asymmetry Mediates Body Mass Index and Treatment Response in Major Depressive Disorder.Depression and anxiety · 2026Article
- The role of chrysanthemum phytochemicals in neural tube development: a narrative review of underlying mechanisms.Frontiers in cell and developmental biology · 2026Review
- A study on the impact of childhood obesity on health-related physical fitness through motor coordination-related functional pathways.Frontiers in nutrition · 2026Article
- Identification of the Critical Life-Stage of Obesity Contributing to Brain Functional Networks.CNS neuroscience & therapeutics · 2025Article
- Reprogramming energy homeostasis in children with overweight through cognitive training and social interaction. A study protocol to estimate leptin sensitivity.Frontiers in endocrinology · 2025Article
- Association of early life cardiovascular risk factors with grey matter structure in young adults in the United Kingdom: the ALSPAC study.EBioMedicine · 2024Article
- Neurometabolic Profile in Obese Patients: A Cerebral Multi-Voxel Magnetic Resonance Spectroscopy Study.Medicina (Kaunas, Lithuania) · 2024Article
- Article
- Neural correlates of obesity across the lifespan.Communications biology · 2024Article
- Spinal afferent neurons: emerging regulators of energy balance and metabolism.Frontiers in molecular neuroscience · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Associations between brain and obesity are bidirectional: changes in brain structure and function underpin over-eating, while chronic adiposity leads to brain atrophy. Investigating brain-obesity interactions across the lifespan can help better understand these relationships. This study explores the interaction between obesity and cortical morphometry in children, young adults, adults, and older adults. We also investigate the genetic, neurochemical, and cognitive correlates of the brain-obesity associations. Our findings reveal a pattern of lower cortical thickness in fronto-temporal brain regions associated with obesity across all age cohorts and varying age-dependent patterns in the remaining brain regions. In adults and older adults, obesity correlates with neurochemical changes and expression of inflammatory and mitochondrial genes. In children and older adults, adiposity is associated with modifications in brain regions involved in emotional and attentional processes. Thus, obesity might originate from cognitive changes during early adolescence, leading to neurodegeneration in later life through mitochondrial and inflammatory mechanisms.
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Registered trials
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