Evidence map›Paper›PMID 38806648›Full record

ArticleScientific reports2024

Early-pregnancy N-terminal pro-brain natriuretic peptide level is inversely associated with hypertensive disorders of pregnancy diagnosed after 35 weeks of gestation.

Masaya Takahashi, Luka Suzuki, Nanase Takahashi, Mayu Hanaue, Masahiro Soda, Tamito Miki, Naoko Tateyama, Shiro Ishihara, Taro Koshiishi

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Masaya TakahashiHagukumi Maternal and Child Clinic, Kanagawa, Japan. dendenkodon@gmail.com.
Luka SuzukiDepartment of Medicine, Diabetes Center, Quantitative Biosciences Institute (QBI), UCSF (University of California San Francisco), San Francisco, CA, USA.
Nanase TakahashiHagukumi Maternal and Child Clinic, Kanagawa, Japan.
Mayu HanaueHagukumi Maternal and Child Clinic, Kanagawa, Japan.
Masahiro SodaHagukumi Maternal and Child Clinic, Kanagawa, Japan.
Tamito MikiHagukumi Maternal and Child Clinic, Kanagawa, Japan.
Naoko TateyamaHagukumi Maternal and Child Clinic, Kanagawa, Japan.
Shiro IshiharaDepartment of Cardiology, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Taro KoshiishiHagukumi Maternal and Child Clinic, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) are among the major causes of high maternal and fetal/neonatal morbidity and mortality rates. Patients with HDP have significantly elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels at diagnosis; however, the NT-proBNP levels during early pregnancy are largely unknown. This study aimed to validate the association between HDP and NT-proBNP levels. This retrospective study evaluated 103 pregnant women who developed HDP diagnosed after 35 weeks of gestation and 667 who did not. The HDP group had significantly lower early-pregnancy NT-proBNP levels than the without HDP group. However, the two groups did not significantly differ in terms of the late-pregnancy NT-proBNP levels. After adjusting for confounding factors such as age, body mass index, parity, and blood pressure levels, high early-pregnancy NT-proBNP levels were associated with a lower HDP risk. Early-pregnancy NT-proBNP levels ≥ 60.5 pg/mL had a negative predictive value of 97.0% for ruling out HDP, with a sensitivity of 87.4% and specificity of 62.5%. In conclusion, elevated early-pregnancy NT-proBNP levels were associated with a lower HDP risk. Moreover, a cutoff point of ≥ 60.5 pg/mL for early-pregnancy NT-proBNP levels had a high negative predictive value and sensitivity for ruling out HDP. These findings can provide new clinical implications.

Indexed as

Hypertension, Pregnancy-InducedNatriuretic Peptide, BrainPeptide FragmentsAdultBiomarkersFemaleGestational AgeHumansPregnancyRetrospective StudiesBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Hypertensive disorders of pregnancyN-terminal pro-brain natriuretic peptide levelsPredictive markerPredictive valuePreeclampsia

Identifiers

PMID38806648
PMCPMC11133404

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