Evidence map›Paper›PMID 38806615›Full record

ArticleScientific reports2024

Bio-distribution and toxicity potential of human umbilical cord mesenchymal stem cells in cynomolgus monkeys.

Ying Huang, Xiaofang Hao, Zhi Lin, Lulu Li, Hua Jiang, Hezhan Zhang, Xingchao Geng, Hao Zhu, Hairuo Wen

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying HuangKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Xiaofang HaoKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Zhi LinKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Lulu LiKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Hua JiangKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Hezhan ZhangKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Xingchao GengKey Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China.
Hao Zhu *Sinoneural Cell Engineering Group Co., Ltd., Shanghai, People's Republic of China. zhuhao@sinoneural.com.
Hairuo Wen *Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, A8 Hongda Middle Road, Beijing, Economic-Technological Development Area, Beijing, 100176, People's Republic of China. wenhairuo@nifdc.org.cn.

Funding

China's National Institute for Food and Drug Control Key Technology Research Fund GJJS-2022-6-1China's National Key Research and Development Program 2021YFA1101602Strategic Priority Research Program of the Chinese Academy of Sciences XDA1604050202
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have demonstrated promising advantages in the therapies of many diseases, while its multi-directional differentiation potential and immunotoxicity are the major concerns hindered their clinical translation. In this study, human umbilical Mesenchymal stem cell (hUC-MSCs) were labeled with a near-infrared fluorescent dye DiR before infused into cynomolgus monkeys, and the amount of hUC-MSCs in the peripheral blood were dynamically estimated from 5 min to 28 days post a single administration at 3 × 10

Indexed as

Macaca fascicularisMesenchymal Stem CellsMesenchymal Stem Cell TransplantationUmbilical CordAnimalsCell DifferentiationFemaleHumansMaleBio-distributionCell therapyCynomolgus monkeyHuman embryonic stem cell differentiation-derived mesenchymal stem cellsSafetyToxicity

Identifiers

PMID38806615
PMCPMC11133417

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.