Evidence map›Paper›PMID 38806494›Full record

ArticleNature communications2024

Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations.

Brooke Szczesny, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Randi K Johnson, Kai Kammers, Emma E Thompson, Madison S Cox, Gautam Shankar, Corey Cox and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Brooke Szczesny *Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Meher Preethi Boorgula *Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Sameer ChavanDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-0220-0845
Monica CampbellDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Randi K JohnsonDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9345-4439
Kai KammersDepartments of Human Genetics, University of Chicago, Chicago, IL, USA.
Emma E ThompsonDivision of Allergy and Infectious Diseases, Dept of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9562-6414
Madison S CoxDivision of Allergy and Infectious Diseases, Dept of Medicine, University of Washington, Seattle, WA, USA.
Gautam ShankarDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Corey CoxDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9042-5982
Andréanne MorinDepartments of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5535-9518
Wendy LorizioDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Michelle DayaDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Samir N P KeladaDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-2676-9232
Terri H BeatyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7644-1705
Ayo P DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Alvaro A CruzFundacao ProAR and Federal University of Bahia, Salvador, Bahia, Brazil.ORCID http://orcid.org/0000-0002-7403-3871
Harold WatsonFaculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital, St. Michael, Bridgetown, Barbados.
Edward T NaureckasDepartments of Medicine, University of Chicago, Chicago, IL, USA.
B Louise GilesDepartments of Pediatrics, University of Chicago, Chicago, IL, USA.
Ganiyu A ArinolaDepartment of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Olumide SogaoluDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Adegoke G FaladeDepartment of Pediatrics, University of Ibadan, and University College Hospital, Ibadan, Nigeria.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Ivana V YangDepartments of Biomedical Informatics and Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Christopher O OlopadeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5759-053X
R Clive LandisEdmund Cohen Laboratory for Vascular Research, George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Cave Hill Campus, Wanstead, Barbados.
Camila A FigueiredoFederal University of Bahia and Funda. Program for Control of Asthma in Bahia (ProAR), Salvador, Brazil.ORCID http://orcid.org/0000-0003-1356-6188
Matthew C AltmanSystems Immunology Program, Benaroya Research Institute, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-1784-8505
Eimear KennyCenter for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Andrew H LiuDepartment of Pediatrics, Childrens Hospital Colorado and University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Carole OberDepartments of Human Genetics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4626-9809
Margaret A TaubDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kathleen C BarnesDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. kathleen.barnes@cuanschutz.edu.
Rasika A MathiasDepartment of Medicine, Johns Hopkins University, Baltimore, MD, USA. rmathias@jhmi.edu.ORCID http://orcid.org/0000-0002-2282-9042

Funding

Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Project-003U19AI162310 · NIAID · UNIVERSITY OF CHICAGO · PI Marcelo A. Nobrega · 2021 to 2026
$10.6M
Multi-omic studies of asthma severity in an African ancestry populationR01AI132476 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, MATHIAS, RASIKA ANN · 2018 to 2022
$3.5M
Systems-level transcriptomic analyses to Identify mouse models of asthmaR01HL122711 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KELADA, SAMIR · 2015 to 2018
$2.0M
NHLBI NIH HHS R01 HL104608NIAID NIH HHS R01 AI132476NIAID NIH HHS U19 AI162310NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES027792U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL104608
6 · The paper itself

Abstract

Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to understand multi-omic signatures of asthma focusing on populations of African ancestry. RNASeq and DNA methylation data are generated from nasal epithelium including cases (current asthma, N = 253) and controls (never-asthma, N = 283) from 7 different geographic sites to identify differentially expressed genes (DEGs) and gene networks. We identify 389 DEGs; the top DEG, FN1, was downregulated in cases (q = 3.26 × 10

Indexed as

AsthmaBlack PeopleDNA MethylationNasal MucosaTacrolimus Binding ProteinsAdultCase-Control StudiesFemaleFibronectinsGene Expression RegulationGene Regulatory NetworksHumansMaleMiddle AgedMultiomicsTacrolimus Binding Protein 5FibronectinsTacrolimus Binding Protein 5Tacrolimus Binding Proteins

Identifiers

PMID38806494
PMCPMC11133339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.