ArticleJornal de pediatria
The trajectory of head circumference and neurodevelopment in very preterm newborns during the first two years of life: a cohort study.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Proteomic analyses in early brain development and neuropathological implications of fetal growth restriction.Neural regeneration research · 2026Article
- Article
- Birth Weight and Neurodevelopmental Disorders Across Diagnostic Categories: A Registry-Based Case-Control Study in Clinically Ascertained Samples.Child psychiatry and human development · 2026Article
- A Bayesian multilevel joint model for predicting neonatal head circumference and body mass index: a case study in Dalahu County, Iran.BMC pregnancy and childbirth · 2026Article
- Two distinct growth patterns of preterm infants from birth to 18 months of corrected gestational age: a retrospective cohort study.Translational pediatrics · 2026Article
- Neurodevelopmental Trajectories in Preterm Neonates: Integrating Neuroimaging Modalities with Clinical Neurological Outcomes.Diagnostics (Basel, Switzerland) · 2026Review
- Hammersmith Infant Neurological Examination at 3 Months in Infants at Risk for Congenital Infections: A Cohort Study.Journal of paediatrics and child health · 2026Observational
- Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD.Annals of clinical and translational neurology · 2025Article
- Three-Dimensional Imaging Sensor-Based Non-Contact Measurement of Neonatal Head Circumference in Incubators.Sensors (Basel, Switzerland) · 2025Article
- Body mass index and head circumference growth charts for the United Arab Emirates-the UAEMCGS 2 study.Scientific reports · 2025Article
- Enhanced versus standard fortification of pasteurized donor human milk for growth in very low birth weight infants: a randomized controlled trial.Frontiers in nutrition · 2025Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the growth trajectory of head circumference and neurodevelopment, and to correlate head circumference with cognitive, language, and motor outcomes during the first two years.
methodProspective cohort study in a tertiary hospital including 95 newborns under 32 weeks or 1500 g. Neonates who developed major neonatal morbidities were excluded. The head circumference was measured at birth, at discharge, and at term-equivalent age, 1, 3, 5, 12, 18, and 24 months of corrected age, and the Bayley Scales (Bayley-III) were applied at 12, 18 and 24 months of corrected age to assess cognitive, language and, motor domains. Scores below 85 were classified as mild/moderate deficits and scores below 70 as severe deficits. The association between head circumference Z score and Bayley scores was assessed using Pearson's correlation. The study considered a significance level of 0.05.
resultsThere was a decrease of -0.18 in the head circumference Z score between birth and discharge and the catch-up occurred between discharge and 1 month (an increase of 0.81 in the Z score). There was a positive correlation between head circumference and Bayley scores at 18 months. There was also a positive correlation between head circumference at discharge and at 5 months with the three domains of the Bayley.
conclusionSerial measurements of head circumference provide knowledge of the trajectory of growth, with early catch-up between discharge and 1 month, as well as its association with neurodevelopment. Head circumference is therefore a valuable clinical marker for neurodevelopment, especially in very preterm newborns.
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