Evidence map›Paper›PMID 38805792›Full record

ReviewMolecular aspects of medicine2024

The uniqueness of on-demand male contraception.

Natalia Del R Rivera Sanchez, Carla Ritagliati, Gregory S Kopf, Steve Kretschmer, Jochen Buck, Lonny R Levin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular aspects of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. David Garbers and the Birth of cAMP Biology in Mammalian Sperm.Molecular reproduction and development · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia Del R Rivera SanchezDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Carla RitagliatiDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Gregory S KopfSacyl Pharmaceuticals, Inc., Old Greenwich, CT, USA.
Steve KretschmerSacyl Pharmaceuticals, Inc., Old Greenwich, CT, USA.
Jochen BuckDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA. Electronic address: jobuck@med.cornell.edu.
Lonny R LevinDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Funding

Target EngagementP50HD113015 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUCK, JOCHEN · 2023 to 2025
$6.0M
Optimization and pre-clinical evaluation of ADCY10 inhibitorsP50HD100549 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVIN, LONNY R · 2019 to 2021
$6.0M
Optimization of lead candidates for an on-demand male contraceptiveR01HD111549 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOCHEN BUCK, LONNY R LEVIN · 2023 to 2026
$2.7M
NICHD NIH HHS P50 HD100549NICHD NIH HHS P50 HD113015NICHD NIH HHS R01 HD111549
6 · The paper itself

Abstract

Because nearly half of pregnancies worldwide are unintended, available contraceptive methods are inadequate. Moreover, due to the striking imbalance between contraceptive options available for men compared to the myriad of options available to women, there is an urgent need for new methods of contraception for men. This review summarizes ongoing efforts to develop male contraceptives highlighting the unique aspects particular to on-demand male contraception, where a man takes a contraceptive only when and as often as needed.

Indexed as

ContraceptionContraceptive Agents, MaleFemaleHumansMalePregnancyContraceptive Agents, MaleNonhormonal male contraceptionOn-demand contraceptionSoluble adenylyl cyclase

Identifiers

PMID38805792
PMCPMC11167369

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.