Evidence map›Paper›PMID 38805696›Full record

ArticleGenetics2024

Clarifying Mendelian vs non-Mendelian inheritance.

Susan Strome, Needhi Bhalla, Rohinton Kamakaka, Upasna Sharma, William Sullivan

Abstract read
In one paragraph

Article in Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susan StromeDepartment of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Needhi BhallaDepartment of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-6859-0073
Rohinton KamakakaDepartment of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Upasna SharmaDepartment of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
William SullivanDepartment of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-1756-4174

Funding

Supplement to support an undergraduate student on Cell Cycle Control in C. elegansR35GM141835 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BHALLA, NEEDHI · 2021 to 2025
$2.5M
Paternal contributions to offspring health: Intergenerational epigenetic inheritance via sperm small RNAsDP2AG066622 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SHARMA, UPASNA · 2019 to 2019
$2.3M
John Templeton Foundation 61748NIA NIH HHS DP2 AG066622NIGMS NIH HHS R35 GM141835NIH HHS R35GM141835
6 · The paper itself

Abstract

Gregor Mendel developed the principles of segregation and independent assortment in the mid-1800s based on his detailed analysis of several traits in pea plants. Those principles, now called Mendel's laws, in fact, explain the behavior of genes and alleles during meiosis and are now understood to underlie "Mendelian inheritance" of a wide range of traits and diseases across organisms. When asked to give examples of inheritance that do NOT follow Mendel's laws, in other words, examples of non-Mendelian inheritance, students sometimes list incomplete dominance, codominance, multiple alleles, sex-linked traits, and multigene traits and cite as their sources the Khan Academy, Wikipedia, and other online sites. Against this background, the goals of this Perspective are to (1) explain to students, healthcare workers, and other stakeholders why the examples above, in fact, display Mendelian inheritance, as they obey Mendel's laws of segregation and independent assortment, even though they do not produce classic Mendelian phenotypic ratios and (2) urge individuals with an intimate knowledge of genetic principles to monitor the accuracy of learning resources and work with us and those resources to correct information that is misleading.

Indexed as

GeneticsAllelesHeredityHumansInheritance PatternsModels, Geneticgeneticsgenotypic and phenotypic ratiosMendelian inheritanceMendel's laws

Identifiers

PMID38805696
PMCPMC11228857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.