Evidence map›Paper›PMID 38805644›Full record

ArticleAdvanced healthcare materials2024

Engineering a Hydrazone and Triazole Crosslinked Hydrogel for Extrusion-Based Printing and Cell Delivery.

Matthew W Jaeschke, Alexandra N Borelli, Nathaniel P Skillin, Timothy J White, Kristi S Anseth

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew W JaeschkeDepartment of Chemical and Biological Engineering, Boulder, CO, 80303, USA.
Alexandra N BorelliDepartment of Chemical and Biological Engineering, Boulder, CO, 80303, USA.
Nathaniel P SkillinDepartment of Chemical and Biological Engineering, Boulder, CO, 80303, USA.
Timothy J WhiteDepartment of Chemical and Biological Engineering, Boulder, CO, 80303, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, Boulder, CO, 80303, USA.ORCID 0000-0002-5725-5691

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Developing near-infrared responsive liquid crystal elastomers for an adjustable pulmonary artery bandF30HL164047 · NHLBI · UNIVERSITY OF COLORADO · PI SKILLIN, NATHANIEL PHILLIP · 2022 to 2025
$172k
BioFrontiers Institute Advanced Light Microscopy Core facility RRID: SCR_018302National Science Foundation Graduate Research Fellowship Program DGE 2040434NHLBI NIH HHS F30 HL164047NHLBI NIH HHS F30HL164047NIDCR NIH HHS R01 DE016523NIDCR NIH HHS R01DE016523U.S. Department of Education Graduate Assistance in Areas of National Need
6 · The paper itself

Abstract

Covalent adaptable crosslinks, such as the alkyl-hydrazone, endow hydrogels with unique viscoelastic properties applicable to cell delivery and bioink systems. However, the alkyl-hydrazone crosslink lacks stability in biologically relevant environments. Furthermore, when formed with biopolymers such as hyaluronic acid (HA), low molecular weight polymers (<60 kDa), or low polymer content (<2 wt%) hydrogels are typically employed as entanglements reduce injectability. Here, a high molecular weight (>60 kDa) HA alkyl-hydrazone crosslinked hydrogel is modified with benzaldehyde-poly(ethylene glycol)

Indexed as

Hyaluronic AcidHydrazonesHydrogelsMesenchymal Stem CellsPolyethylene GlycolsTriazolesAnimalsCell SurvivalCross-Linking ReagentsCycloaddition ReactionHumansCross-Linking ReagentsHyaluronic AcidHydrazonesHydrogelsPolyethylene GlycolsTriazolescovalent adaptable networksextrusion‐based printinghydrazoneinjectable hydrogelsmesenchymal stem cell

Identifiers

PMID38805644
PMCPMC11305943

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.