Evidence map›Paper›PMID 38805611›Full record

ArticleJMIR public health and surveillance2024

A Bayesian System to Detect and Track Outbreaks of Influenza-Like Illnesses Including Novel Diseases: Algorithm Development and Validation.

John M Aronis, Ye Ye, Jessi Espino, Harry Hochheiser, Marian G Michaels, Gregory F Cooper

Abstract readValidation Study
In one paragraph

Article in JMIR public health and surveillance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Using natural language processing in emergency medicine health service research: A systematic review and meta-analysis.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

John M AronisDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0001-5821-3672
Ye YeDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0002-1138-9846
Jessi EspinoDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0001-8104-2656
Harry HochheiserDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0001-8793-9982
Marian G MichaelsDepartment of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0002-2556-0544
Gregory F CooperDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0002-9276-773X

Funding

MIDAS Coordination CenterU24GM132013 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOCHHEISER, HARRY S · 2019 to 2023
$8.1M
Automated Surveillance of Overlapping Outbreaks and New Outbreak DiseasesR01LM013509 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, GREGORY F. · 2021 to 2023
$1.0M
Transfer learning to improve the re-usability of computable biomedical knowledgeR00LM013383 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YE, YE · 2022 to 2024
$710k
NIGMS NIH HHS U24 GM132013NLM NIH HHS R00 LM013383NLM NIH HHS R01 LM013509
6 · The paper itself

Abstract

backgroundThe early identification of outbreaks of both known and novel influenza-like illnesses (ILIs) is an important public health problem.

objectiveThis study aimed to describe the design and testing of a tool that detects and tracks outbreaks of both known and novel ILIs, such as the SARS-CoV-2 worldwide pandemic, accurately and early.

methodsThis paper describes the ILI Tracker algorithm that first models the daily occurrence of a set of known ILIs in hospital emergency departments in a monitored region using findings extracted from patient care reports using natural language processing. We then show how the algorithm can be extended to detect and track the presence of an unmodeled disease that may represent a novel disease outbreak.

resultsWe include results based on modeling diseases like influenza, respiratory syncytial virus, human metapneumovirus, and parainfluenza for 5 emergency departments in Allegheny County, Pennsylvania, from June 1, 2014, to May 31, 2015. We also include the results of detecting the outbreak of an unmodeled disease, which in retrospect was very likely an outbreak of the enterovirus D68 (EV-D68).

conclusionsThe results reported in this paper provide support that ILI Tracker was able to track well the incidence of 4 modeled influenza-like diseases over a 1-year period, relative to laboratory-confirmed cases, and it was computationally efficient in doing so. The system was also able to detect a likely novel outbreak of EV-D68 early in an outbreak that occurred in Allegheny County in 2014 as well as clinically characterize that outbreak disease accurately.

Indexed as

AlgorithmsBayes TheoremDisease OutbreaksInfluenza, HumanCOVID-19Emergency Service, HospitalHumansPennsylvaniaalgorithmBayesian modelingbiosurveillancecoronavirusCOVID-19disease modelingemergency departmententerovirus D68hospitalhospitalshuman metapneumovirusinfluenzainfluenza-like illnessesnatural language processingNLPnovel diseasenovel diseasesoutbreakparainfluenzapatient carePennsylvaniapublic healthrespiratory syncytialSARS-CoV-2surveillance

Identifiers

PMID38805611
PMCPMC11350309

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.