Evidence map›Paper›PMID 38805498›Full record

ArticlePloS one2024

Assessment of the localization of chondroitin sulfate in various types of endometrial carcinoma.

Sho Hosokawa, Yoshiaki Norimatsu, Akiko Shinagawa, Tetsuji Kurokawa, Yoshio Yoshida, Takeshi Nishikawa, Hisae Suzuki, Satoshi Irino, Tadao K Kobayashi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sho HosokawaDepartment of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.ORCID 0000-0001-7802-3753
Yoshiaki NorimatsuDepartment of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.ORCID 0000-0002-5733-906X
Akiko ShinagawaDepartment of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Tetsuji KurokawaDepartment of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Yoshio YoshidaDepartment of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takeshi NishikawaDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Hisae SuzukiDepartment of Pathology, Nara Medical University Hospital, Nara, Japan.
Satoshi IrinoDepartment of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.
Tadao K KobayashiExecutive Director, Tenri University, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to assess the localization of chondroitin sulfate (CS), a primary extracellular matrix component, in the stromal region of endometrial carcinoma (EC).

methodsImmunostaining was performed on 26 endometrial endometrioid carcinoma (EEC) samples of different grades and 10 endometrial serous carcinoma (ESC) samples to evaluate CS localization. This was further confirmed by Alcian Blue (AB) staining as well.

resultsIn the G1-EEC samples, CS showed reactivity with fibrovascular stroma, supporting closely packed glandular crowding and papillary structures. As the grade increased, the original interstitial structure was re-established, and the localization of CS in the perigulandular region decreased. In the ESC samples, the thick fibrous strands supporting the papillary architecture showed reactivity with CS; however, the delicate stromal region branching into the narrow region showed poor reactivity. The AB staining results showed similar characteristics to the immunostaining ones.

conclusionsThe characteristic localization of CS in various EC types was elucidated. The present study provides new information on endometrial stromal assessment.

Indexed as

Chondroitin SulfatesEndometrial NeoplasmsAgedCarcinoma, EndometrioidFemaleHumansImmunohistochemistryMiddle AgedChondroitin Sulfates

Identifiers

PMID38805498
PMCPMC11132439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.