Evidence map›Paper›PMID 38805270›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.

Yuta Otobe, Eui Min Jeong, Shunsuke Ito, Yuta Shinohara, Nobuhiro Kurabayashi, Atsu Aiba, Yoshitaka Fukada, Jae Kyoung Kim, Hikari Yoshitane

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  7. Article
  8. Review
  9. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. A daily cycle of White Collar Complex dephosphorylation sustains circadian rhythmicity inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuta Otobe *Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0009-0009-3527-1621
Eui Min Jeong *Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon 34141, Republic of Korea.
Shunsuke Ito *Department of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0009-0007-8215-8707
Yuta ShinoharaDivision of Molecular Psychoimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Kita-Ku, Sapporo 060-0815, Japan.
Nobuhiro KurabayashiCircadian Clock Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8506, Japan.
Atsu AibaDepartment of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0002-8192-0778
Yoshitaka FukadaDepartment of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0003-2096-6008
Jae Kyoung KimBiomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon 34141, Republic of Korea.ORCID 0000-0001-7842-2172
Hikari YoshitaneDepartment of Biological Sciences, School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Funding

Institute for Basic Science (IBS) IBS-R029-C3Japan Agency for Medical Research and Development (AMED) 20gm6110010h0004Japan Agency for Medical Research and Development (AMED) 22gm4010019h0001MEXT | Japan Science and Technology Agency (JST) JPMJFR2150Ministry of Education, Culture, Sports, Science and Technology (MEXT) 17H06096Ministry of Education, Culture, Sports, Science and Technology (MEXT) 21H05130Ministry of Education, Culture, Sports, Science and Technology (MEXT) 21K18231Samsung Science and Technology Foundation (SSTF) RGY0063/2017Samsung Science and Technology Foundation (SSTF) SSTF-BA1902-01
6 · The paper itself

Abstract

In mammals, CLOCK and BMAL1 proteins form a heterodimer that binds to E-box sequences and activates transcription of target genes, including

Indexed as

ARNTL Transcription FactorsCircadian ClocksCLOCK ProteinsPeriod Circadian ProteinsAnimalsCircadian RhythmDNAHEK293 CellsHumansMiceMutationNIH 3T3 CellsPhosphorylationProtein BindingProtein DomainsARNTL Transcription FactorsBMAL1 protein, humanBmal1 protein, mouseCLOCK protein, humanClock protein, mouseCLOCK ProteinsDNAPER2 protein, humanPer2 protein, mousePeriod Circadian Proteinscircadian rhythmCRISPR-Cas9DNA bindingmathematical modelingphosphorylation

Identifiers

PMID38805270
PMCPMC11161756

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.