Evidence map›Paper›PMID 38804861›Full record

ArticleImmunity, inflammation and disease2024

The circulating IL-35

Qian Li, Cuixia Yang, Cheng Liu, Yuehui Zhang, Ningyu An, Xiumei Ma, Yang Zheng, Xiaomin Cui, Qian Li

Abstract read
In one paragraph

Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The role and mechanism of IL‑35 in myasthenia gravis (Review).International journal of molecular medicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. The circulating IL-35Immunity, inflammation and disease · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian LiDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0000-0003-3525-0360
Cuixia YangDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0003-2145-7886
Cheng LiuMedical Science Research Institution of Ningxia Hui Autonomous Region, Medical Sci-Tech Research Center of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0006-8973-7034
Yuehui ZhangDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0006-3350-1524
Ningyu AnDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0000-8810-3490
Xiumei MaDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0008-7754-2429
Yang ZhengDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0007-3985-7115
Xiaomin CuiDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.ORCID 0009-0002-5880-0396
Qian LiDepartment of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, The Third Affiliated Clinical College of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.

Funding

National Natural Science Foundation of China 81960184
6 · The paper itself

Abstract

backgroundThyroid-associated ophthalmopathy (TAO) is the most common orbital disease in adults, potentially leading to disfigurement and visual impairment. However, the causes of TAO are not fully understood. IL-35

methodsThis study enrolled 36 healthy individuals and 14 TAO patients. We isolated peripheral blood mononuclear cells and stimulated them with IL-35 and CpG for 48 h. Flow cytometry was used to measure the percentages of IL-35

resultsThe percentage of circulating IL-35

conclusionsOur results suggest a potential role of IL-35

Indexed as

B-Lymphocytes, RegulatoryGraves OphthalmopathyInterleukinsAdultAgedFemaleHumansMaleMiddle Agedinterleukin-35, humanInterleukinsIL‐35regulatory B cellsthyroid associated ophthalmology

Identifiers

PMID38804861
PMCPMC11131934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.