Evidence map›Paper›PMID 38804596›Full record

ArticleClinical and translational allergy2024

Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK-air study.

Bernardo Sousa-Pinto, Gilles Louis, Rafael J Vieira, Wienczyslawa Czarlewski, Josep M Anto, Rita Amaral, Ana Sá-Sousa, Luisa Brussino, G Walter Canonica, Claudia Chaves Loureiro and 53 more

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Article in Clinical and translational allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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63 authors.

Bernardo Sousa-PintoMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Gilles LouisDepartment of Public Health, University of Liège, Liège, Belgium.ORCID https://orcid.org/0000-0001-7111-285X
Rafael J VieiraMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0003-1834-3055
Wienczyslawa CzarlewskiMedical Consulting Czarlewski, Levallois, France.
Josep M AntoISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Rita AmaralMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Ana Sá-SousaMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Luisa BrussinoDepartment of Medical Sciences, University of Torino, Torino, Italy.
G Walter CanonicaDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Claudia Chaves LoureiroDepartment of Pneumology, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal.
Alvaro A CruzFundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil.
Bilun GemiciogluDepartment of Pulmonary Diseases, Faculty of Medicine, Istanbul University-Cerrahpaşa, Cerrahpaşa, Istanbul, Turkey.
Tari HaahtelaSkin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Maciej KupczykDivision of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
Violeta KvedarieneInstitute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Desirée E Larenas-LinnemannCenter of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.ORCID https://orcid.org/0000-0002-5713-5331
Nhân Pham-ThiEcole Polytechnique de Palaiseau, Palaiseau, France.
Francesca PuggioniIRCCS Humanitas Research Center, Personalized Medicine Asthma & Allergy, Rozzano, Milan, Italy.
Frederico S RegateiroAllergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Jan RomantowskiDepartment of Allergology, Medical University of Gdańsk, Gdansk, Poland.
Joaquin SastreAllergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain.
Nicola ScichilonePROMISE Department, University of Palermo, Palermo, Italy.
Luis Taborda-BarataUBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Maria Teresa VenturaAllergy and Clinical Immunology, University of Bari Medical School, Bari, Italy.ORCID https://orcid.org/0000-0002-2637-4583
Ioana AgacheFaculty of Medicine, Transylvania University Brasov, Brasov, Romania.
Anna BedbrookMASK-air, Montpellier, France.
Alida BenfantePROMISE Department, University of Palermo, Palermo, Italy.
Karl C BergmannInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sinthia Bosnic-AnticevichQuality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
Matteo BoniniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Louis-Philippe BouletQuebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
Guy BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Roland BuhlDepartment of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany.
Lorenzo CecchiSOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
Denis CharpinClinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France.
Elisio M CostaCINTESIS@RISE, Biochemistry Lab, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto, Porto, Portugal.
Stefano Del GiaccoDepartment of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
Marek JutelDepartment of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
Ludger KlimekDepartment of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
Piotr KunaDivision of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
Daniel LauneKYomed INNOV, Montpellier, France.
Mika MakelaSkin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Mario Morais-AlmeidaAllergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
Rachel NadifUniversité Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France.
Marek NiedoszytkoUBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
Nikolaos G PapadopoulosAllergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
Alberto PapiRespiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.ORCID https://orcid.org/0000-0002-6924-4500
Oliver PfaarSection of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID https://orcid.org/0000-0003-4374-9639
Daniela Rivero-YeverinoServicio de Alergia e Inmunología clínica, Hospital Universitario de Puebla, Puebla, México.
Nicolas RocheInserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France.
Boleslaw SamolinskiDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
Mohamed H ShamjiNational Heart and Lung Institute (NHLI), Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-3425-3463
Aziz SheikhUsher Institute, The University of Edinburgh, Edinburgh, UK.
Charlotte Suppli UlrikDepartment of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark.
Omar S UsmaniNational Heart and Lung Institute (NHLI), Imperial College London, London, UK.
Arunas ValiulisInterdisciplinary Research Group of Human Ecology, Institute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
Arzu YorganciogluDepartment of Pulmonary Diseases, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
Torsten ZuberbierInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1466-8875
Joao A FonsecaMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Benoit PétréDepartment of Public Health, University of Liège, Liège, Belgium.
Renaud LouisGIGA I3 Research Group, University of Liège, Liège, Belgium.
Jean BousquetMASK-air, Montpellier, France.ORCID https://orcid.org/0000-0002-4061-4766
MASK‐air think tankMASK-air think tank-See Section 6.

Funding

Allergologisk Laboratorium KøbenhavnAsthma and Rhinitis project of the European Institute of Innovation and Technology HealthDG Santé and DG ConnectEducational grants from Mylan-ViatrisEspíritu Santo UniversityGlaxoSmithKlineH2020 and Horizon EuropeLiège UniversityNoucorNovartisProvence-Alpes-Côte d'AzurRégion Languedoc RoussillonSamborondon EcuadorStallergènes-GreerStructural and Development FundsTwinning, European Innovation Partnership on Active and Healthy Ageing
6 · The paper itself

Abstract

rationaleIt is unclear how each individual asthma symptom is associated with asthma diagnosis or control.

objectivesTo assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.

methodsIn this cross-sectional study, we assessed real-world data using the MASK-air MEASUREMENT AND MAIN

resultsWe included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma.

conclusionsWheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.

Indexed as

asthmadiagnosisdyspneamHealthwheezing

Identifiers

PMID38804596
PMCPMC11304469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.