Evidence map›Paper›PMID 38804592›Full record

ArticleAnimal biotechnology2024

Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats.

Ruqing Xu, Man Bai, Yixing Fan, Yubo Zhu, Zeying Wang, Taiyu Hui, Qi Zhang, Xingwang Liu, Jialiang Zhang, Jincheng Shen and 1 more

Abstract read
In one paragraph

Article in Animal biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Animals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruqing XuCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Man BaiCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Yixing FanCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Yubo ZhuCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Zeying WangCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Taiyu HuiCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Qi ZhangCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Xingwang LiuCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Jialiang ZhangCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Jincheng ShenCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.
Wenlin BaiCollege of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inducing activation event of secondary hair follicle (SHF)-stem cells is considered a key biological process in the SHF regeneration, and the morphogenesis of cashmere fiber in cashmere goats. The miR-361-5p was essentially implicated in the induced activation of SHF-stem cells of cashmere goats, but its functional mechanisms are unclear. Here, we confirmed miR-361-5p was significantly downregulated in anagen SHF bugle of cashmere goats compared with that at telogen, and miR-361-5p expression was significantly lower in SHF-stem cells after activation than its counterpart before activation. Further, we found that miR-361-5p could negatively regulate the induced activation event of SHF-stem cells in cashmere goats. Mechanistically, through dual-luciferase reporter assays, miR-361-5p specifically bound with

Indexed as

Forkhead Box Protein M1GoatsMicroRNAsStem CellsWnt Signaling PathwayAnimalsGene Knockdown TechniquesHair FollicleForkhead Box Protein M1MicroRNAscashmere goatsFOXM1induced activationMiR-361-5pSHF-stem cells

Identifiers

PMID38804592
PMCPMC12674437

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.