Evidence map›Paper›PMID 38804217›Full record

ArticleJournal of the American Heart Association2024

Technical and Clinical Outcomes After Transcatheter Edge-to-Edge Repair of Mitral Regurgitation in Male and Female Patients: Is Equality Achieved?

Luigi Biasco, Gregorio Tersalvi, Catherine Klersy, Giovanni Benfari, Patric Biaggi, Roberto Corti, Moreno Curti, Oliver Gaemperli, Raban Jeger, Francesco Maisano and 9 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Inpatient Outcomes of Tricuspid Transcatheter Edge-to-Edge Repair in the United States Based on Sex.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Luigi BiascoDepartment of Biomedical Sciences University of Italian Switzerland Lugano Switzerland.ORCID 0000-0002-9173-3992
Gregorio TersalviDivision of Cardiology Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale Lugano Switzerland.ORCID 0000-0003-1845-1777
Catherine KlersyService of Biostatistics & Clinical Trial Center Fondazione IRCCS Policlinico San Matteo Pavia Italy.ORCID 0000-0003-0314-8548
Giovanni BenfariDivision of Cardiology, Department of Medicine University of Verona Verona Italy.ORCID 0000-0002-5660-6162
Patric BiaggiHeart Clinic Zurich, Hirslanden Zurich Switzerland.
Roberto CortiHeart Clinic Zurich, Hirslanden Zurich Switzerland.ORCID 0000-0003-4598-7470
Moreno CurtiService of Biostatistics & Clinical Trial Center Fondazione IRCCS Policlinico San Matteo Pavia Italy.
Oliver GaemperliHeart Clinic Zurich, Hirslanden Zurich Switzerland.
Raban JegerDivision of Cardiology Triemli Hospital Zürich and University of Basel Basel Switzerland.ORCID 0000-0003-1290-5491
Francesco MaisanoDivision of Cardiovascular Surgery San Raffaele University Hospital Milano Milan Italy.ORCID 0000-0002-3691-1709
Olivier MuellerDivision of Cardiology University Hospital Lausanne Lausanne Switzerland.ORCID 0000-0003-2441-5799
Barbara NaegeliDivision of Cardiology Klinik Im Park Zürich Switzerland.
Stephane NobleDivision of Cardiology University Hospital Geneve Geneva Switzerland.ORCID 0000-0002-8018-2857
Fabien PrazDivision of Cardiology University Hospital Bern Bern Switzerland.ORCID 0000-0001-5416-165X
Stefan ToggweilerDivision of Cardiology, Kantonsspital Luzern Lucerne Switzerland.ORCID 0000-0002-7860-0298
Marco ValgimigliDepartment of Biomedical Sciences University of Italian Switzerland Lugano Switzerland.ORCID 0000-0002-4353-7110
Yvonne CristoforettiDepartment of Biomedical Sciences University of Italian Switzerland Lugano Switzerland.
Maurice Enriquez-SaranoValve Science Research Center Minneapolis Heart Institute Minneapolis MN USA.ORCID 0000-0003-0910-5450
Giovanni PedrazziniDepartment of Biomedical Sciences University of Italian Switzerland Lugano Switzerland.ORCID 0000-0002-6513-3985

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, no clear impact of sex on short- and long-term survival following transcatheter edge-to-edge mitral valve repair (TEER) is evident, although no data are available on postprocedural life expectancy. Our aim was to assess sex-specific differences in outcomes of patients with mitral regurgitation (MR) treated by TEER. METHODS AND

resultsShort-term and 5-year outcomes in men and women undergoing TEER between 2011 and 2018 who were included in the large, multicenter, real-world MitraSwiss registry were analyzed. Outcomes were compared stratified by sex and according to MR cause (primary versus secondary). The impact of TEER on postprocedural life expectancy was estimated by relative survival analysis. Among 1142 patients aged 60 to 89 years, 39.8% were women. They were older, with fewer cardiovascular risk factors and lower functional capacity compared with men. Thirty-day mortality was higher in men than in women (3.3% versus 1.1%; odds ratio, 3.16 [95% CI, 1.16-10.7];

conclusionsTEER is not associated with increased short-term mortality in women, whereas 5-year outcomes are comparable between sexes. Moreover, TEER completely restored normal life expectancy in women with primary MR. A residual excess mortality persists in secondary MR, independently of sex.

Indexed as

Cardiac CatheterizationMitral Valve InsufficiencyRegistriesAgedAged, 80 and overFemaleHeart Valve Prosthesis ImplantationHumansLife ExpectancyMaleMiddle AgedMitral ValveRisk FactorsSex FactorsTime FactorsTreatment Outcomeedge‐to‐edge mitral valve repairmitral regurgitationmortalitypercutaneous mitral valve repairsex

Identifiers

PMID38804217
PMCPMC11255636

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.