Evidence map›Paper›PMID 38804149›Full record

ArticleThe Journal of antimicrobial chemotherapy2024

The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions.

Yonah Hebron Mwalwisi, Adam Mitangu Fimbo, Ludwig Hoellein, Moses Nandonde, Gerald Sambu, Babuali Ahmed, Abdalla Juma, Siya Augustine, Danstan Hipolite Shewiyo, Eliangiringa Amos Kaale and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yonah Hebron MwalwisiHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Adam Mitangu FimboHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Ludwig HoelleinPharmaceutical and Medicinal Chemistry, Institute for Pharmacy and Food Chemistry, Universität Würzburg, 97074 Würzburg, Germany.
Moses NandondeHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Gerald SambuHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Babuali AhmedHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Abdalla JumaHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Siya AugustineHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Danstan Hipolite ShewiyoHuman and Veterinary Medicines, Tanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, Tanzania.
Eliangiringa Amos KaalePharm R&D Lab, School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65545, 11103, Upanga West, Dar es Salaam, Tanzania.ORCID 0000-0001-6008-3539
Ulrike HolzgrabePharmaceutical and Medicinal Chemistry, Institute for Pharmacy and Food Chemistry, Universität Würzburg, 97074 Würzburg, Germany.ORCID 0000-0002-0364-7278

Funding

Tanzania Medicines and Medical Devices Authority
6 · The paper itself

Abstract

objectivesThe quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia.

methodsSamples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively.

resultsA total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs.

conclusionsThere was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs.

Indexed as

Anti-Bacterial AgentsCiprofloxacinQuality ControlAmoxicillinCeftriaxoneHumansTabletsTanzaniaAmoxicillinAnti-Bacterial AgentsCeftriaxoneCiprofloxacinTablets

Identifiers

PMID38804149
PMCPMC11215545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.