ArticleInfection control and hospital epidemiology2024
Relationship between chlorhexidine gluconate concentration and microbial colonization of patients' skin.
Article in Infection control and hospital epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07039955 (Effectiveness of Daily Chlorhexidine Bathing and Antibiotic and Proton Pump Inhibitor), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Daily Chlorhexidine Bathing and Antibiotic and Proton Pump Inhibitor (PPI) Stewardship in Preventing Transmission and Infection Caused by Carbapenemase-Producing Enterobacteriaceae (CPE)
Who cites it
3 citing papers in PubMed.
- Can chlorhexidine gluconate baths reduce fungal colonisation in intensive care unit patients?Antimicrobial resistance and infection control · 2025Article
- Prospective, crossover, comparative study of two methods of chlorhexidine bathing.Infection control and hospital epidemiology · 2025Article
- Chlorhexidine gluconate skin levels and organism decolonization: what we know and what we don't know.Infection control and hospital epidemiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
objectiveTo characterize the relationship between chlorhexidine gluconate (CHG) skin concentration and skin microbial colonization.
designSerial cross-sectional study. SETTING/
participantsAdult patients in medical intensive care units (ICUs) from 7 hospitals; from 1 hospital, additional patients colonized with carbapenemase-producing Enterobacterales (CPE) from both ICU and non-ICU settings. All hospitals performed routine CHG bathing in the ICU.
methodsSkin swab samples were collected from adjacent areas of the neck, axilla, and inguinal region for microbial culture and CHG skin concentration measurement using a semiquantitative colorimetric assay. We used linear mixed effects multilevel models to analyze the relationship between CHG concentration and microbial detection. We explored threshold effects using additional models.
resultsWe collected samples from 736 of 759 (97%) eligible ICU patients and 68 patients colonized with CPE. On skin, gram-positive bacteria were cultured most frequently (93% of patients), followed by
conclusionsOn a cross-sectional basis, higher CHG skin concentrations were associated with less detection of gram-positive bacteria and
Identifiers
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Registered trials
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