Evidence map›Paper›PMID 38803975›Full record

ArticleHeliyon2024

Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns.

Paul-Rémi Petit, Franck Touret, Jean-Sélim Driouich, Maxime Cochin, Léa Luciani, Ornéllie Bernadin, Caroline Laprie, Géraldine Piorkowski, Laurent Fraisse, Peter Sjö and 7 more

Abstract read
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Paul-Rémi PetitUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Franck TouretUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Jean-Sélim DriouichUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Maxime CochinUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Léa LucianiUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Ornéllie BernadinUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Caroline LaprieLaboratoire Vet-Histo, Marseille, France.
Géraldine PiorkowskiUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Laurent FraisseDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Peter SjöDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Charles E MowbrayDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Fanny EscudiéDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Ivan ScandaleDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Eric ChatelainDrugs for Neglected Diseases Initiative, Geneva, Switzerland.
Xavier de LamballerieUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Caroline SolasUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.
Antoine NougairèdeUnité des Virus Émergents (UVE: Aix-Marseille Univ, Università di Corsica, IRD 190, Inserm 1207, IRBA), France.

Funding

Wellcome Trust
6 · The paper itself

Abstract

The SARS-CoV-2 pandemic has highlighted the need for broad-spectrum antiviral drugs to respond promptly to viral emergence. We conducted a preclinical study of molnupiravir (MOV) against SARS-CoV-2 to fully characterise its antiviral properties and mode of action. The antiviral activity of different concentrations of MOV was evaluated

Indexed as

Animal modelAntiviral drugCOVID-19HAEMutagenesisNucleoside analog

Identifiers

PMID38803975
PMCPMC11128822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.