ArticleFrontiers in neurology2024
Anxiety mediates association between sex and jaw function limitation in temporomandibular disorder patients from China.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Associations between caffeine consumption, anxiety, temporomandibular disorders, and oral behaviors in university students in Brazil-a cross-sectional study.Journal of oral & facial pain and headache · 2026Article
- Sex differences in pain in 2 large and diverse US databases.Pain reports · 2026Article
- Regional cutaneous and muscle sensitivity does not mediate changes in active mouth opening in temporomandibular disorders: a cross-sectional study.Journal of oral & facial pain and headache · 2025Article
- The Link Between Temporomandibular Disorders and Jaw Functional Limitations Among Chinese Adolescents.International dental journal · 2025Article
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Authors and funding
7 authors.
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Abstract
Aim: The objective of this study is to explore the relationship between sex and jaw function and to test whether anxiety mediates the causal relationship between sex and jaw function in temporomandibular disorders (TMDs) patients. Methods: A total of 488 participants with TMD were included in the analysis. Demographic data were collected. Generalized anxiety symptoms and anxiety severity were initially assessed using the GAD-7 questionnaire. And jaw function limitation was measured using the JFLS-8 scale. A directed acyclic graph (DAG) was used in this study to evaluate the hypotheses. Mediation analysis was conducted to explore causality and to calculate the total effect, natural direct effect (NDE) and natural indirect effect (NIE). Results: In TMD patients, there was a significant association between female and jaw function ( Conclusion: A causal mechanism was found that anxiety acts as a mediator of sex effects on jaw function. Therefore, psychological factors need to be taken into account in the treatment of female TMD patients. Further clinical trials are needed to explore whether psychotherapy is more beneficial to improve jaw function in female TMD patients.
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