Evidence map›Paper›PMID 38803576›Full record

ArticleFrontiers in aging2024

Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems.

Patricio Arrué, Kaveh Laksari, Mark Russo, Tana La Placa, Meghan Smith, Nima Toosizadeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Patricio ArruéDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.
Kaveh LaksariDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.
Mark RussoDepartment of Surgery, Division of Cardiac Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Tana La PlacaDepartment of Surgery, Division of Cardiac Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Meghan SmithDepartment of Surgery, Division of Cardiac Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
Nima ToosizadehDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.

Funding

Phase II STTR: Portable Device for Telecare Monitoring of Elderly PeopleR42AG032748 · NIA · BIOSENSICS, LLC · PI GWIN, JOSEPH T, MOHLER, MARTHA JANE · 2012 to 2016
$2.7M
Heart Rate Dynamics in Response to Upper-Extremity Function Test to Identify Irreversible Frailty After Invasive Therapy in Older Adults with Advanced Heart DiseaseR01AG076774 · NIA · UNIVERSITY OF ARIZONA · PI Nima Toosizadeh · 2023 to 2026
$1.3M
Functional Capacity Assessment in Hospitalized Bed-bound COPD Patients; Predicting OutcomesR21AG059202 · NIA · UNIVERSITY OF ARIZONA · PI MOHLER, MARTHA JANE, TOOSIZADEH, NIMA · 2019 to 2020
$410k
NIA NIH HHS R01 AG076774NIA NIH HHS R21 AG059202NIA NIH HHS R42 AG032748
6 · The paper itself

Abstract

Frailty is a geriatric syndrome associated with the lack of physiological reserve and consequent adverse outcomes (therapy complications and death) in older adults. Recent research has shown associations between heart rate (HR) dynamics (HR changes during physical activity) with frailty. The goal of the present study was to determine the effect of frailty on the interconnection between motor and cardiac systems during a localized upper-extremity function (UEF) test. Fifty-six individuals aged 65 or above were recruited and performed the previously developed UEF test consisting of 20-s rapid elbow flexion with the right arm. Frailty was assessed using the Fried phenotype. Wearable gyroscopes and electrocardiography were used to measure motor function and HR dynamics. In this study, the interconnection between motor (angular displacement) and cardiac (HR) performance was assessed, using convergent cross-mapping (CCM). A significantly weaker interconnection was observed among pre-frail and frail participants compared to non-frail individuals (

Indexed as

cardiac autonomic systemconvergent cross-mapping (CCM)frailtyheart rate dynamicsmotor performancephysiology networkupper-extremity functionwearable sensors

Identifiers

PMID38803576
PMCPMC11128670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.