Evidence map›Paper›PMID 38803541›Full record

SynthesisFrontiers in aging neuroscience2024

Intraoperative electroencephalogram patterns as predictors of postoperative delirium in older patients: a systematic review and meta-analysis.

Valery V Likhvantsev, Levan B Berikashvili, Anastasia V Smirnova, Petr A Polyakov, Mikhail Ya Yadgarov, Nadezhda D Gracheva, Olga E Romanova, Irina S Abramova, Maria M Shemetova, Artem N Kuzovlev

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06809556 (Association of Processed Electroencephalography Derived Parameters with Postoperative Delirium in Patients with Parkinson's Disease Undergoing Elective Neurosurgery), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06809556 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Association of Processed Electroencephalography Derived Parameters with Postoperative Delirium in Patients with Parkinson's Disease Undergoing Elective Neurosurgery

TypeobservationalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2025 to 2027Enrolled40ConditionsPost Operative Delirium, Parkinson DiseaseArmsEEG (electroencephalogram) monitoring of Parkinson's patients undergoing deep brain stimulation
3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valery V LikhvantsevFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Levan B BerikashviliFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Anastasia V SmirnovaFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Petr A PolyakovFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Mikhail Ya YadgarovFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Nadezhda D GrachevaFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Olga E RomanovaFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Irina S AbramovaDepartment of Anesthesiology, City Clinical Oncological Hospital No. 1, Moscow, Russia.
Maria M ShemetovaFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.
Artem N KuzovlevFederal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology, Department of Clinical Trials, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative delirium (POD) significantly affects patient outcomes after surgery, leading to increased morbidity, extended hospital stays, and potential long-term cognitive decline. This study assessed the predictive value of intraoperative electroencephalography (EEG) patterns for POD in adults. Methods: This systematic review and meta-analysis followed the PRISMA and Cochrane Handbook guidelines. A thorough literature search was conducted using PubMed, Medline, and CENTRAL databases focusing on intraoperative native EEG signal analysis in adult patients. The primary outcome was the relationship between the burst suppression EEG pattern and POD development. Results: From the initial 435 articles identified, 19 studies with a total of 7,229 patients were included in the systematic review, with 10 included in the meta-analysis (3,705 patients). In patients exhibiting burst suppression, the POD incidence was 22.1% vs. 13.4% in those without this EEG pattern (p=0.015). Furthermore, an extended burst suppression duration associated with a higher likelihood of POD occurrence ( Conclusions: This study revealed a 41% increase in the relative risk of developing POD in cases where a burst suppression pattern was present. These results underscore the clinical relevance of intraoperative EEG monitoring in predicting POD in older patients, suggesting its potential role in preventive strategies. Systematic Review Registration: This study was registered on International Platform for Registered Protocols for Systematic Reviews and Meta-Analyses: INPLASY202420001, https://doi.org/10.37766/inplasy2024.2.0001.

Indexed as

anesthesiaburst suppressionintraoperative EEGmeta-analysispostoperative deliriumsurgerysystematic review

Identifiers

PMID38803541
PMCPMC11128674

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.