Evidence map›Paper›PMID 38803421›Full record

ArticleMolecular therapy. Nucleic acids2024

Sequencing-guided design of genetically encoded small RNAs targeting CAG repeats for selective inhibition of mutant

Mansi A Parasrampuria, Adam A White, Ramadevi Chilamkurthy, Adrian A Pater, Fatima El-Azzouzi, Katy N Ovington, Philip J Jensik, Keith T Gagnon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mansi A ParasrampuriaDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Adam A WhiteDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Ramadevi ChilamkurthyDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Adrian A PaterDepartment of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901, USA.
Fatima El-AzzouziDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Katy N OvingtonDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Philip J JensikDivision of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Keith T GagnonDivision of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by genetic expansion of a CAG repeat sequence in one allele of the

Indexed as

allele-selectiveCAG repeatgene therapyHTTHuntington’s diseasemiRNAMT: Oligonucleotides: Therapies and Applicationsoff-target effectssequencingshRNA

Identifiers

PMID38803421
PMCPMC11129097

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.