Evidence map›Paper›PMID 38803392›Full record

ArticleFrontiers in cell and developmental biology2024

Membrane potential hyperpolarization: a critical factor in acrosomal exocytosis and fertilization in sperm within the female reproductive tract.

Paula A Balestrini, Valeria Sulzyk, Martina Jabloñski, Liza J Schiavi-Ehrenhaus, Soledad N González, Juan J Ferreira, Matías D Gómez-Elías, Pablo Pomata, Guillermina M Luque, Dario Krapf and 3 more

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Paula A BalestriniInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Valeria SulzykInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Martina JabloñskiInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Liza J Schiavi-EhrenhausInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Soledad N GonzálezInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Juan J FerreiraDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, MO, United States.
Matías D Gómez-ElíasInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Pablo PomataInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Guillermina M LuqueInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Dario KrapfInstituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas-Universidad Nacional de Rosario, Rosario, Santa Fe, Argentina.
Patricia S CuasnicuInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.
Celia M SantiDepartment of OB/GYN, Washington University School of Medicine, Saint Louis, MO, United States.
Mariano G BuffoneInstituto de Biología y Medicina Experimental (IByME)-Consejo Nacional de Investigaciones Científicas y Tícnicas, Buenos Aires, Argentina.

Funding

SLO3 KO MOUSE: A TOOL TO REVEAL VOLTAGE-DEPENDENT PROCESSES IN SPERM FERTILITYR01HD069631 · NICHD · WASHINGTON UNIVERSITY · PI SANTI, CELIA M · 2011 to 2022
$3.3M
Regulation of Soluble Adenylate Cyclase During Mammalian Sperm CapacitationR01HD106968 · NICHD · COLORADO STATE UNIVERSITY · PI Diego Krapf · 2022 to 2026
$1.5M
NICHD NIH HHS R01 HD069631NICHD NIH HHS R01 HD106968
6 · The paper itself

Abstract

Hyperpolarization of the membrane potential (Em), a phenomenon regulated by SLO3 channels, stands as a central feature in sperm capacitation-a crucial process conferring upon sperm the ability to fertilize the oocyte.

Indexed as

acrosomal exocytosiscapacitationfertilizationhyperpolarizationmatingoviductsperm

Identifiers

PMID38803392
PMCPMC11128623

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.