Evidence map›Paper›PMID 38803308›Full record

ArticleObesity (Silver Spring, Md.)2024

Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.

Andrea M Brennan, Paul M Coen, Theresa Mau, Megan Hetherington-Rauth, Frederico G S Toledo, Erin E Kershaw, Peggy M Cawthon, Philip A Kramer, Sofhia V Ramos, Anne B Newman and 11 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Andrea M BrennanTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.ORCID 0000-0003-3092-7344
Paul M CoenTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Theresa MauSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Megan Hetherington-RauthSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Frederico G S ToledoDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Erin E KershawDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Philip A KramerDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sofhia V RamosTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Anne B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Daniel E FormanDivisions of Geriatrics and Cardiology, Department of Medicine, University of Pittsburgh, Geriatric Research Education and Clinical Center (GRECC), VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.
Reichelle X YeoTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Giovanna DistefanoTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Iva MiljkovicDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jamie N JusticeDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Anthony J A MolinaDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Michael J JurczakDivision of Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lauren M SparksTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.
Stephen B KritchevskyDepartment of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Bret H GoodpasterTranslational Research Institute, AdventHealth Research Institute, Orlando, Florida, USA.

Funding

PREVENTABLE Vanguard PhaseU19AG065188 · NIA · DUKE UNIVERSITY · PI KAREN P ALEXANDER · 2019 to 2026
$96.2M
Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Modified Application of Cardiac Rehabilitation (CR) for Older Adults (MACRO)R01AG060499 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORMAN, DANIEL E. · 2018 to 2022
$5.0M
Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)R01AG066474 · NIA · ADVENTHEALTH ORLANDO · PI KERSHAW, ERIN E., SPARKS, LAUREN MARIE · 2020 to 2024
$3.8M
Blood Base Bioenergetic Profiling: A Novel Approach for Identifying Alzheimer's Disease Risk and PathologyR01AG054523 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOLINA, ANTHONY J, NICKLAS, BARBARA J · 2017 to 2021
$3.8M
Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's DiseaseR01AG061805 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOLINA, ANTHONY J · 2018 to 2022
$3.5M
Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)R01AG073633 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Brian Richard Lindman · 2022 to 2026
$3.2M
Aging Biomarkers: Integrating Omic Profiles with Mechanistic MeasuresU01AG060897 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO, DING, JINGZHONG · 2018 to 2022
$3.2M
HSRD VA I01 HX003518NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1TR001420NIA NIH HHS K01 AG059837NIA NIH HHS P30 AG021332NIA NIH HHS P30AG021332NIA NIH HHS P30 AG024827NIA NIH HHS P30AG024827NIA NIH HHS P30 AG068635NIA NIH HHS R01 AG054523NIA NIH HHS R01 AG058883NIA NIH HHS R01 AG059416NIA NIH HHS R01AG059416NIA NIH HHS R01 AG060499NIA NIH HHS R01 AG061805NIA NIH HHS R01 AG066474NIA NIH HHS R01AG066474NIA NIH HHS R01 AG072734NIA NIH HHS R01 AG073633NIA NIH HHS R01 AG077179NIA NIH HHS U01 AG060897NIA NIH HHS U19 AG065188NIDDK NIH HHS R01 DK114012RRD VA I21 RX004409Wellcome Trust
6 · The paper itself

Abstract

objectiveThe aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults.

methodsCross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized in vivo (

resultsIndependent of BMI, total abdominal AT (standardized [Std.] β = -0.21; R

conclusionsSkeletal MFI and abdominal visceral, but not subcutaneous, AT are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA.

Indexed as

Body Mass IndexEnergy MetabolismMuscle, SkeletalAdipose TissueAgedAged, 80 and overBody Fat DistributionCross-Sectional StudiesFemaleHumansIntra-Abdominal FatMagnetic Resonance ImagingMaleMitochondria, MuscleOxidative Phosphorylation

Identifiers

PMID38803308
PMCPMC11139412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.