Evidence map›Paper›PMID 38803266›Full record

Trial reportBMJ open2024

Cost-effectiveness of strength exercise or aerobic exercise compared with usual care for patients with knee osteoarthritis: secondary results from a multiarm randomised controlled trial in Norway.

Rikke Munk Killingmo, Britt Elin Øiestad, May-Arna Risberg, Esther Maas, Margreth Grotle

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01682980 (Efficacy of Strength and Aerobic Exercise on Patient-reported Outcomes in Patients With Knee Osteoarthritis - A Randomised Controlled Trial.), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01682980 naactive not recruitingnot on this map

Efficacy of Strength and Aerobic Exercise on Patient-reported Outcomes in Patients With Knee Osteoarthritis - A Randomised Controlled Trial.

TypeinterventionalSponsorOslo University HospitalRan2013 to 2025Enrolled207ConditionsOsteoarthritis, PainArmsStrength training, Aerobic exercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rikke Munk KillingmoDepartment of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Norway rikke@oslomet.no.ORCID 0000-0003-1971-2449
Britt Elin ØiestadDepartment of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Norway.ORCID 0000-0002-0547-9781
May-Arna RisbergDivision of Orthopaedic Surgery, Oslo Universitetssykehus, Oslo, Norway.
Esther MaasDepartment of Health Sciences, Vrije University Amsterdam, Amsterdam, The Netherlands.
Margreth GrotleDepartment of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Norway.ORCID 0000-0001-8243-1143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the 1-year cost-effectiveness of strength exercise or aerobic exercise compared with usual care for patients with symptomatic knee osteoarthritis (OA), from a societal and healthcare perspective.

designCost-effectiveness analysis embedded in a three-arm randomised controlled trial. PARTICIPANTS AND

settingA total of 161 people with symptomatic knee OA seeking Norwegian primary or secondary care were included in the analyses.

interventionsParticipants were randomised to either 12 weeks of strength exercise (n=54), 12 weeks of aerobic exercise (n=53) or usual care (n=54). OUTCOME MEASURES: Quality-adjusted life-years (QALYs) estimated by the EuroQol-5 Dimensions-5 Levels, and costs related to healthcare utilisation and productivity loss estimated in euros (€), aggregated for 1 year of follow-up. Cost-effectiveness was expressed with mean incremental cost-effectiveness ratios (ICERs). Bootstrapping was used to estimate ICER uncertainty.

resultsFrom a 1-year societal perspective, the mean cost per patient was €7954, €8101 and €17 398 in the strength exercise, aerobic exercise and usual care group, respectively. From a 1-year healthcare perspective, the mean cost per patient was €848, €2003 and €1654 in the strength exercise, aerobic exercise and usual care group, respectively. Mean differences in costs significantly favoured strength exercise and aerobic exercise from a 1-year societal perspective and strength exercise from a 1-year healthcare perspective. There were no significant differences in mean QALYs between groups. From a 1-year societal perspective, at a willingness-to-pay threshold of €27 500, the probability of strength exercise or aerobic exercise being cost-effective was ≥98%. From a 1-year healthcare perspective, the probability of strength exercise or aerobic exercise being cost-effective was ≥97% and ≥76%, respectively.

conclusionFrom a 1-year societal and healthcare perspective, a 12-week strength exercise or aerobic exercise programme is cost-effective compared with usual care in patients with symptomatic knee OA. TRIAL REGISTRATION NUMBER: NCT01682980.

Indexed as

Cost-Benefit AnalysisExercise TherapyOsteoarthritis, KneeQuality-Adjusted Life YearsResistance TrainingAgedExerciseFemaleHealth Care CostsHumansMaleMiddle AgedNorwayhealth economicsphysical therapy modalitiesprimary health care

Identifiers

PMID38803266
PMCPMC11328638

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.