Evidence map›Paper›PMID 38803235›Full record

ArticleLife science alliance2024

Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoforms.

Samantha G Fernandez, Lucas Ferguson, Nicholas T Ingolia

Abstract read
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Samantha G FernandezDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Lucas FergusonDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Nicholas T IngoliaDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA ingolia@berkeley.edu.ORCID 0000-0002-3395-1545

Funding

Molecular Basis and Cellular Roles of Translational RegulationDP2CA195768 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI INGOLIA, NICHOLAS T · 2014 to 2014
$2.4M
Functional genomics of the dynamic molecular network controlling mRNA translation and decayR01GM130996 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI INGOLIA, NICHOLAS T · 2019 to 2022
$1.2M
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
NCI NIH HHS DP2 CA195768NIGMS NIH HHS R01 GM130996NIH HHS S10 OD018174
6 · The paper itself

Abstract

Translation initiation at alternative start sites can dynamically control the synthesis of two or more functionally distinct protein isoforms from a single mRNA. Alternate isoforms of the developmental transcription factor CCAAT/enhancer-binding protein α (C/EBPα) produced from different start sites exert opposing effects during myeloid cell development. This choice between alternative start sites depends on sequence features of the

Indexed as

CCAAT-Enhancer-Binding Protein-alphaProtein BiosynthesisProtein IsoformsRibosomesAnimalsHEK293 CellsHumansMicePeptide Chain Initiation, TranslationalRNA, MessengerTOR Serine-Threonine KinasesCCAAT-Enhancer-Binding Protein-alphaProtein IsoformsRNA, MessengerTOR Serine-Threonine Kinases

Identifiers

PMID38803235
PMCPMC11109482

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.