Evidence map›Paper›PMID 38803132›Full record

ArticleAutism research : official journal of the International Society for Autism Research2024

Profiles of minimally verbal autistic children: Illuminating the neglected end of the spectrum.

Maria Pizzano, Stephanie Shire, Wendy Shih, Lynne Levato, Rebecca Landa, Catherine Lord, Tristram Smith, Connie Kasari

2 registry-linked trialsAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01018407 nacompletednot on this map

Multisite Randomized Control Treatment of Early Intervention for Spoken Communication in Autism

TypeinterventionalSponsorUniversity of California, Los AngelesRan2009 to 2015Enrolled192ConditionsAutismArmsDiscrete Trial Training, Interpersonal Developmental Approach
NCT01751698 nacompletednot on this map

Adaptive Interventions for Minimally Verbal Children With ASD in the Community

TypeinterventionalSponsorUniversity of California, Los AngelesRan2013 to 2017Enrolled192ConditionsAutismArmsJASP-EMT, DTT
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Proportion and Profile of Autistic Children Not Acquiring Spoken Language Despite Receiving Evidence-Based Early Interventions.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria PizzanoDepartment of Psychiatry, UCLA, Los Angeles, California, USA.ORCID 0000-0003-1312-7740
Stephanie ShireSchool of Education, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0002-0023-2376
Wendy ShihDepartment of Psychiatry, UCLA, Los Angeles, California, USA.
Lynne LevatoDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
Rebecca LandaCenter for Autism Services, Sciences, and Innovation (CASSI), Kennedy Krieger Institute, Baltimore, Maryland, USA.
Catherine LordDepartment of Psychiatry, UCLA, Los Angeles, California, USA.ORCID 0000-0001-5633-1253
Tristram SmithDepartment of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA.
Connie KasariDepartment of Psychiatry, UCLA, Los Angeles, California, USA.ORCID 0000-0003-2266-170X

Funding

Adaptive Interventions for Minimally Verbal Children with ASD in the CommunityR01HD073975 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2012 to 2016
$13.0M
Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM)R01HD095973 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2019 to 2024
$3.2M
Mechanisms of Change with Early Intervention in Tuberous Sclerosis ComplexR01HD090138 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESTE, SHAFALI SPURLING · 2017 to 2022
$3.1M
1/3-Multisite RCT of Early Intervention for Spoken Communication in AutismR01MH084864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2009 to 2013
$2.7M
The CCS: A Treatment Outcome Measure for Individuals with Severe IDR01HD076903 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI BRADY, NANCY CAROLINE, FLEMING, KANDACE KAY · 2013 to 2017
$1.7M
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Child Health and Human Development RO1HD073975NICHD NIH HHS R01 HD073975NICHD NIH HHS R01 HD076903NICHD NIH HHS R01 HD090138NICHD NIH HHS R01 HD095973NIH HHS 1R01HD095973-01A1NIH HHS R01HD090138-01A1NIMH NIH HHS 1R01MH084864-01A1NIMH NIH HHS R01 MH084864
6 · The paper itself

Abstract

Heterogeneity among individuals on the autism spectrum is widely acknowledged as a barrier to develop effective interventions. Overcoming this challenge requires characterization of individual differences, especially for children that are minimally verbal and often excluded from research studies. Most studies that describe autistic subgroups identify a single minimally verbal verbal group based on a single identifying measure (e.g., ADOS module one or single item indicating absence of phrase speech). Determining personalized courses of intervention requires a more detailed understanding since a single intervention will not be effective for all who are minimally verbal. The present study identified comprehensive profiles of cognitive, language, and social communication skills within a large, diverse, group of minimally verbal children with autism. The analysis combined baseline data from two studies to yield a sample of 344 participants, who were 3 to 8 years old at the time of study onset, with 60% who identified as having a race/ethnicity other than White. Via latent profile analysis (LPA), a three-group model was identified as best fit to the data. Profile identification was dependent on a participant's combination of cognitive, expressive, and social communication characteristics, rather than a single domain. One group (n = 206) had global delays, while the other two groups (n = 95 and n = 43) had variable strengths in cognition and communication. Findings suggest that low-frequency/minimally verbal communicators with autism have heterogeneous characteristics that can be systematically organized.

Indexed as

Autism Spectrum DisorderChildChild, PreschoolCognitionCommunicationFemaleHumansMaleautism spectrum disorderdiversityheterogeneitylatent profile analysisminimally verbalnonverbalsubgroups

Identifiers

PMID38803132
PMCPMC11186722

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.