ArticleLipids in health and disease2024
Is inflammation a missing link between relative handgrip strength with hyperlipidemia? Evidence from a large population-based study.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Association between preoperative prognostic nutritional index and postoperative delirium in older adults with hip fractures: a real-world study.Annals of medicine · 2026Article
- Preoperative neutrophil-to-lymphocyte ratio and refracture risk in hip fracture patients: a propensity score-matched analysis.Annals of medicine · 2026Article
- Lipophagy Dynamics in Hyperlipidemia Model ICR Mice Across Different High-Fat-Diet Feeding Durations.International journal of molecular sciences · 2026Article
- The Mediating Role of Inflammation in the Association Between NHHR and Pelvic Inflammatory Disease: A Case-Control Study Based on Machine Learning.Journal of inflammation research · 2026Article
- Association between erectile dysfunction and relative fat mass in adult men in the United States.Translational andrology and urology · 2025Article
- Sex- and Age-Stratified relative handgrip strength and risk of eight chronic diseases in Middle-Aged and older adults: evidence from a National aging cohort study in China.Aging clinical and experimental research · 2025Article
- Co-exposure to heat and noise on workers' health: evidence from a large-scale cross-sectional surveillance study in China.BMC public health · 2025Article
- Association of lipid accumulation product with the prevalence and incidence of sarcopenia: a nationwide study in Chinese.Nutrition & metabolism · 2025Article
- Prognostic nutritional index, sarcopenia, and risk of mortality: a national population-based study.Nutrition & metabolism · 2025Article
- Association between prognostic nutritional index and risk of moderate-to-severe basic activities of daily living dependence two years after hip fracture surgery in older adults.BMC geriatrics · 2025Article
- Association Between Lipid Accumulation Product and Stress Urinary Incontinence in Women in the United States: The Mediating Role of Oxidative Stress.International neurourology journal · 2025Article
- Association between dietary index for gut microbiota and chronic kidney disease: A cross-sectional study from U.S. population.Preventive medicine reports · 2025Article
- Association between lipid accumulation products and relative handgrip strength: a large population-based study.Scientific reports · 2025Article
- Inflammatory markers partially mediate the association between volatile organic compounds exposure and hyperlipidemia: a nationally representative cross-sectional study from NHANES.Frontiers in public health · 2025Article
- Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis.International journal of chronic obstructive pulmonary disease · 2025Article
- Associations of cardiometabolic index with diabetic statuses and insulin resistance: the mediating role of inflammation-related indicators.BMC public health · 2024Article
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11 authors.
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Abstract
backgroundRelative handgrip strength (RHGS) was positively correlated with healthy levels of cardiovascular markers and negatively correlated with metabolic disease risk. However, its association with hyperlipidemia remains unknown. The present study investigated the link between RHGS and hyperlipidemia, utilizing data from the National Health and Nutrition Examination Survey (NHANES) and further examined the hypothesis that inflammation may serve a mediating role within this relationship.
methodsData were extracted from 4610 participants in the NHANES database spanning 2011-2014 to explore the correlation between RHGS and hyperlipidemia using multivariate logistic regression models. Subgroup analyses were conducted to discern the correlation between RHGS and hyperlipidemia across diverse populations. Additionally, smooth curve fitting and threshold effect analysis were conducted to validate the association between RHGS and hyperlipidemia. Furthermore, the potential mediating effect of inflammation on this association was also explored.
resultsAccording to the fully adjusted model, RHGS was negatively correlated with hyperlipidemia [odds ratio (OR) = 0.575, 95% confidence interval (CI) = 0.515 to 0.643], which was consistently significant across all populations, notably among women. Smooth curve fitting and threshold effect analysis substantiated the negative association between RHGS and hyperlipidemia. Moreover, the mediating effects analysis indicated the white blood cell (WBC) count, neutrophil (Neu) count, and lymphocyte (Lym) count played roles as the mediators, with mediation ratios of 7.0%, 4.3%, and 5.0%, respectively.
conclusionsThis study identified a prominent negative correlation between RHGS and hyperlipidemia. Elevated RHGS may serve as a protective factor against hyperlipidemia, potentially through mechanisms underlying the modulation of inflammatory processes.
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