Evidence map›Paper›PMID 38802728›Full record

ArticlePediatric blood & cancer2024

Investigating home-based opioid use among youth with sickle cell disease using ecological momentary assessment.

Cecelia Valrie, B Sloan Crawford, Jelaina Shipman-Lacewell, Opeyemi Ajibade, Beng Fuh, Wally Smith, India Sisler

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Article in Pediatric blood & cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Cecelia ValrieDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0002-7204-6812
B Sloan CrawfordDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jelaina Shipman-LacewellDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
Opeyemi AjibadeDepartment of Pediatric Hematology Oncology, Division of Pediatric Hematology, The Children's Hospital at Montefiore, Bronx, New York, USA.
Beng FuhDepartment of Pediatrics, Division of Pediatric Hematology and Oncology, East Carolina University, Greenville, North Carolina, USA.
Wally SmithDepartment of Internal Medicine, Division of General Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
India SislerDepartment of Pediatrics, Division of Pediatric Hematology and Oncology, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0002-6018-5620

Funding

Using E-Diaries to Assess Sleep and Pain in Children and Adolescents with SickleK01HL103155 · NHLBI · EAST CAROLINA UNIVERSITY · PI VALRIE, CECELIA R · 2010 to 2014
$603k
Predicting Pediatric Sickle Cell Disease Acute Pain Using Mathematical Models Based on mHealth DataR21DE032583 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCGEE, REGINALD, VALRIE, CECELIA R · 2022 to 2022
$420k
The Role of Sleep and Community-Level Supports in the Association between Racial Discrimination and Cardiometabolic Health in Black AdolescentsF31MD017954 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI SHIPMAN-LACEWELL, JELAINA RUTH · 2022 to 2023
$87k
National Heart and Lung InstituteNational Institute of Minority Health and Health DisparitiesNHLBI NIH HHS K01 HL103155NIDCR NIH HHS R21 DE032583NIMHD NIH HHS F31 MD017954NINDS NIH HHS
6 · The paper itself

Abstract

backgroundOpioids are a common and essential treatment for acute sickle cell disease (SCD) pain. However, opioids carry well-known adverse side effects, including potential development of hyperalgesia and nociplastic pain. We characterized opioid use in youth with SCD using ecological momentary assessment (EMA) data, and investigated the relationships between home-based opioid use, pain, and a range of biopsychosocial factors.

methodEighty-eight youth with SCD (aged 8-17 years) completed EMAs assessing home-based opioid use, pain, and related factors. Analyses consisted of descriptive and multilevel logistic regression to predict daily home opioid use.

resultsYouth averaged 3.64 weeks of EMAs. Approximately 35% of the sample (n = 31) took an opioid during the EMA period, and used them on only 24% of reported pain days. Youth who took opioids reported a higher percentage of pain days (t = -2.67, p < .05) and mean pain severity scores (t = -2.30, p < .05) than youth who did not take opioids. Multilevel logistic regression analyses indicated that high daily pain severity (odds ratio [OR] = 1.02, p < .01), older age (OR = 1.324, p < .01), and low positive affect (OR = 0.91, p < .01) were each related to an increased likelihood of opioid use.

conclusionYouth with SCD take opioids appropriately in response to their pain, based on daily self-report. Beyond daily pain severity, age, and daily variation in positive affect were related to home-based opioid use. This suggests that behavioral interventions that enhance positive affect may promote reduced opioid use among youth with SCD.

Indexed as

Analgesics, OpioidAnemia, Sickle CellEcological Momentary AssessmentAdolescentChildFemaleHumansMalePainPain ManagementAnalgesics, Opioidecological momentary assessmentopioidspediatricpositive affectsickle cell disease

Identifiers

PMID38802728
PMCPMC11211048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.