Evidence map›Paper›PMID 38802690›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

The role of EEG and neuroimaging in the diagnosis of non-convulsive status epilepticus in Subacute Encephalopathy with Seizures in Alcoholics (SESA syndrome): a case report and overview of the literature.

Erica Biassoni, Margherita Bellucci, Elisa Micalizzi, Marco Miggino, Enzo Andorno, Elisa Porcile, Martina Resaz, Luca Roccatagliata, Lucio Castellan, Flavio Villani and 1 more

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erica Biassoni *Department of Neuroscience, Neurorehabilitation, Ophthalmology, Genetics, and Mother and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Margherita Bellucci *Department of Neuroscience, Neurorehabilitation, Ophthalmology, Genetics, and Mother and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Elisa MicalizziNeurophysiology Unit and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy. elisa.micalizzi@hsanmartino.it.ORCID http://orcid.org/0000-0003-3991-3918
Marco MigginoHBP and Liver Transplant Surgery Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Enzo AndornoHBP and Liver Transplant Surgery Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Elisa PorcilePostoperative Intensive Care Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Martina ResazNeuroradiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Luca RoccatagliataNeuroradiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Lucio CastellanNeuroradiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Flavio VillaniNeurophysiology Unit and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Alessandra FerrariNeurophysiology Unit and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epileptic seizures are frequently associated with liver dysfunction and alcoholism. Subacute encephalopathy with seizures in chronic alcoholics (SESA) is an underrecognized condition with peculiar clinical, EEG and neuroradiological features.We report the case of a 58-year-old man with previous alcohol use disorder (AUD) and acute-on chronic liver failure on alcohol-related cirrhosis, referred for urgent Orthotopic Liver Transplantation evaluation. The patient presented with delirium, aphasia and progressive deterioration of consciousness leading to intensive care unit admission. EEG showed slow activity with superimposed lateralized periodic discharges (LPDs) over the left temporo-occipital regions and ictal discharges with focal motor phenomena, consistent with focal status epilepticus. Antiseizure treatment with lacosamide and levetiracetam was administered with progressive improvement of consciousness.Brain MRI disclosed T2/FLAIR areas of hyperintensity in the left pulvinar and T2/FLAIR hyperintensity with corresponding DWI hyperintensity in the left hippocampal cortex, suggestive of post/peri-ictal excitotoxic changes with anatomical correspondence to focal LPDs distribution. SWI demonstrated decreased prominence of cortical veins in the left temporo-occipital region consistent with increased venous blood oxygenation in compensatory hyperperfusion.In conclusion, SESA should be suspected in the differential diagnosis of patients with AUD presenting with focal neurological deficits, seizures and focal EEG abnormalities. In this context, EEG and brain MRI represent useful tools with both diagnostic and prognostic value.

Indexed as

AlcoholismElectroencephalographyStatus EpilepticusBrainHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingSeizuresBrain MRIFocal status epilepticusLateralized periodic discharges (LPDs)Subacute encephalopathy with seizures in chronic alcoholics (SESA)

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.