Evidence map›Paper›PMID 38802619›Full record

ArticleNeurosurgical review2024

Association between elevated preoperative red cell distribution width and mortality after brain tumor craniotomy.

Peng Wang, Yu Zhang, Wenhao Xu, Yuxin Zheng, Lu Jia, Jialing He, Miao He, Lvlin Chen, Pengfei Hao, Yangchun Xiao and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peng WangDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China.
Yu ZhangCenter for Evidence-Based Medical, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Wenhao XuCenter for Evidence-Based Medical, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yuxin ZhengCenter for Evidence-Based Medical, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Lu JiaDepartment of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Jialing HeDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China.
Miao HeDepartment of Anesthesia, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Lvlin ChenDepartment of Critical Care Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Pengfei HaoCenter for Evidence-Based Medical, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yangchun XiaoCenter for Evidence-Based Medical, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Liyuan PengDepartment of Critical Care Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Weelic ChongDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Yang HaiSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Chao YouDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China.
Fang FangDepartment of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China. fangfang01@scu.edu.cn.

Funding

Experimental Teaching Research and Reform Project of Chengdu University cdsyjg2022022Science and Technology Research Project of Chongqing Municipal Education Commission KJQN20220045Sichuan Provincial Natural Science Foundation 2023NSFSC1564the 1·3·5 project for disciplines of excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University 21HXFH046the innovation team project of Affiliated Hospital of Clinical Medicine College of Chengdu University CDFYCX202203the project of health commission of Sichuan province 2019HR50the project of Sichuan Science and Technology Bureau 22ZDYF0798
6 · The paper itself

Abstract

backgroundRed cell distribution width (RDW) has been recognized as a potential inflammatory biomarker, with elevated levels associated with adverse outcomes in various diseases. However, its role in predicting outcomes after brain tumor craniotomy remains unclear. We aimed to assess whether preoperative RDW influences mortality and postoperative complications in patients undergoing brain tumor craniotomy.

methodsThis retrospective cohort study analyzed serum RDW levels in patients undergoing brain tumor craniotomy at West China Hospital. RDW was evaluated in two forms: RDW-CV and RDW-SD, and was categorized into four quartiles for analysis by using logistic regression and multivariate analysis to adjust for confounding.

resultsThe study encompassed 10,978 patients undergoing brain tumor craniotomy. our analysis revealed no significant difference in 30-day mortality across various RDW-CV levels. However, we observed a dose-response relationship with preoperative RDW-CV levels in assessing long-term mortality risks. Specifically, patients with RDW-CV levels of 12.6-13.2% (HR 1.04, 95% CI 1.01-1.18), 13.2-13.9% (HR 1.12, 95% CI 1.04-1.26), and > 13.9% (HR 1.34, 95% CI 1.18-1.51) exhibited a significantly higher hazard of long-term mortality compared to those with RDW-CV < 12.6%. When preoperative RDW-CV was analyzed as a continuous variable, for each 10% increase in RDW-CV, the adjusted OR of long-term mortality was 1.09 (95% CI 1.05-1.13). we also observed significant associations between preoperative higher RDW-CV levels and certain postoperative complications including acute kidney injury (OR 1.46, 95% CI: 1.10-1.94), pneumonia infection (OR 1.19 95% CI: 1.05-1.36), myocardial infarction (OR 1.32, 95% CI: 1.05-1.66), readmission (OR 1.15, 95% CI: 1.01-1.30), and a prolonged length of hospital stay (OR 1.11, 95% CI: 1.02-1.21). For RDW-SD levels, there was no significant correlation for short-term mortality, long-term mortality, and postoperative complications.

conclusionsOur study showed elevated preoperative RDW-CV is significantly associated with increased long-term mortality and multiple postoperative complications, but no such association is observed with RDW-SD. These findings show the prognostic importance of RDW-CV, reinforcing its potential as a valuable tool for risk stratification in the preoperative evaluation of brain tumor craniotomy patients.

Indexed as

Brain NeoplasmsCraniotomyErythrocyte IndicesPostoperative ComplicationsAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesBrain tumorInflammation biomarkerMortalityPrognosisRed cell distribution width

Identifiers

PMID38802619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.