ArticleEuropean journal of epidemiology2024
Source-specific nitrate intake and all-cause mortality in the Danish Diet, Cancer, and Health Study.
Article in European journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies.GeroScience · 2025Pooled it
- Review
- Exploring the associations between dietary nitrate and nitrite intake and markers of self-reported periodontal disease in the UK Biobank cohort.European journal of nutrition · 2026Article
- Dietary Sources of Nitrate and Nitrite and Associations with Blood Pressure and Other Cardiovascular Disease Risk Factors in a Representative United Kingdom Population.The Journal of nutrition · 2026Article
- Dietary exposure to N-nitrosamines and their precursors: an age-stratified assessment.Scientific reports · 2026Article
- The compartmentalization model of nitrate homeostasis: Role of the salivary glands, skeletal muscle, and liver.EXCLI journal · 2026Review
- Source-specific nitrate intake and incident dementia in the Danish Diet, Cancer and Health Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Prospective association between dietary source-determined nitrate/nitrite and the risk of metabolic syndrome among children and adolescents: Tehran lipid and glucose study.Nutrition journal · 2025Article
- The butterfly effect: collateral damage and impacts of antimicrobial strategies on the oral microbiome.npj antimicrobials and resistance · 2025Review
- Isolation, characterization, and genomic analysis of3 Biotech · 2025Article
- Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Gastric Cancer: A Multicase-Control Study in Spain (MCC-Spain).Environmental health perspectives · 2025Article
- Effects of Animal-Based and Plant-Based Nitrates and Nitrites on Human Health: Beyond Nitric Oxide Production.Biomolecules · 2025Review
- Chronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.American journal of physiology. Endocrinology and metabolism · 2025Article
- Nitrate, Nitrite, and Iodine Concentrations in Commercial Edible Algae: An Observational Study.Foods (Basel, Switzerland) · 2024Article
- Editorial: Dietary nitrate: friend or foe.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNitrate and nitrite are naturally occurring in both plant- and animal-sourced foods, are used as additives in the processing of meat, and are found in water. There is growing evidence that they exhibit a spectrum of health effects, depending on the dietary source. The aim of the study was to examine source-dependent associations between dietary intakes of nitrate/nitrite and both all-cause and cause-specific mortality.
methodsIn 52,247 participants of the Danish Diet, Cancer and Health Study, associations between source-dependent nitrate and nitrite intakes--calculated using comprehensive food composition and national drinking water quality monitoring databases--and all-cause, cardiovascular disease (CVD)-related, and cancer-related mortality over 27 years were examined using restricted cubic splines within Cox proportional hazards models adjusting for demographic, lifestyle, and dietary confounders. Analyses were stratified by factors hypothesised to influence the formation of carcinogenic N-nitroso compounds (namely, smoking and dietary intakes of vitamin C, vitamin E, folate, and polyphenols).
resultsPlant-sourced nitrate intake was inversely associated with all-cause mortality [HR
conclusionNitrate/nitrite from plant sources are inversely associated while those from naturally occurring animal-sources, additive-permitted meat sources, and tap water-sources are positively associated with mortality.
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