Evidence map›Paper›PMID 38802496›Full record

ArticleScientific reports2024

HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia.

I Raykhel, V-P Ronkainen, J Myllyharju, A Manninen

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

I RaykhelDisease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland.
V-P RonkainenExtracellular Matrix and Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland.
J Myllyharju *Extracellular Matrix and Hypoxia Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland. johanna.myllyharju@oulu.fi.ORCID http://orcid.org/0000-0001-7772-1250
A Manninen *Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland. aki.manninen@oulu.fi.ORCID http://orcid.org/0000-0002-6263-8101

Funding

Academy of Finland 114344Academy of Finland 135560Academy of Finland 251314Academy of Finland 263770Academy of Finland 296498FibroGen JM
6 · The paper itself

Abstract

Hypoxia-inducible factors (HIF) 1 and 2 regulate similar but distinct sets of target genes. Although HIFs are best known for their roles in mediating the hypoxia response accumulating evidence suggests that under certain conditions HIFs, particularly HIF2, may function also under normoxic conditions. Here we report that HIF2α functions under normoxic conditions in kidney epithelial cells to regulate formation of adherens junctions. HIF2α expression was required to induce Dock4/Rac1/Pak1-signaling mediating stability and compaction of E-cadherin at nascent adherens junctions. Impaired adherens junction formation in HIF2α- or Dock4-deficient cells led to aberrant cyst morphogenesis in 3D kidney epithelial cell cultures. Taken together, we show that HIF2α functions in normoxia to regulate epithelial morphogenesis.

Indexed as

Adherens JunctionsBasic Helix-Loop-Helix ProteinsCell Polarityrac1 GTP-Binding ProteinSignal TransductionAnimalsCadherinsCell LineEndothelial PAS Domain-Containing Protein 1Epithelial CellsGTPase-Activating ProteinsHumansMicep21-Activated KinasesBasic Helix-Loop-Helix ProteinsCadherinsEndothelial PAS Domain-Containing Protein 1GTPase-Activating Proteinsp21-Activated Kinasesrac1 GTP-Binding ProteinAdherens junctionCancerHIFHypoxiaKidney epithelial polarity

Identifiers

PMID38802496
PMCPMC11130225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.