Evidence map›Paper›PMID 38802397›Full record

ArticleNature communications2024

Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration.

Gengxi Lu, Chen Gong, Yizhe Sun, Xuejun Qian, Deepthi S Rajendran Nair, Runze Li, Yushun Zeng, Jie Ji, Junhang Zhang, Haochen Kang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. A flexible photoacoustic retinal prosthesis.bioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Emerging Wearable Acoustic Sensing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Review
  12. Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Gengxi Lu *Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7497-050X
Chen Gong *Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6262-704X
Yizhe SunDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9291-0076
Xuejun QianDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3634-8757
Deepthi S Rajendran NairRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8851-5241
Runze LiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6642-5904
Yushun ZengDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5995-4085
Jie JiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Junhang ZhangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7847-3102
Haochen KangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6818-8092
Laiming JiangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Jiawen ChenDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Chi-Feng ChangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Biju B ThomasRoski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0312-4450
Mark S HumayunDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA. qifazhou@usc.edu.ORCID http://orcid.org/0000-0003-1527-3020

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
Biomechanical mapping of the optic nerve head and peripapillary sclera using high frequency ultrasonic elastographyR01EY032229 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2021 to 2024
$2.6M
Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY028662NEI NIH HHS R01 EY030126NEI NIH HHS R01 EY032229
6 · The paper itself

Abstract

Retinal degeneration, a leading cause of irreversible low vision and blindness globally, can be partially addressed by retina prostheses which stimulate remaining neurons in the retina. However, existing electrode-based treatments are invasive, posing substantial risks to patients and healthcare providers. Here, we introduce a completely noninvasive ultrasonic retina prosthesis, featuring a customized ultrasound two-dimensional array which allows for simultaneous imaging and stimulation. With synchronous three-dimensional imaging guidance and auto-alignment technology, ultrasonic retina prosthesis can generate programmed ultrasound waves to dynamically and precisely form arbitrary wave patterns on the retina. Neuron responses in the brain's visual center mirrored these patterns, evidencing successful artificial vision creation, which was further corroborated in behavior experiments. Quantitative analysis of the spatial-temporal resolution and field of view demonstrated advanced performance of ultrasonic retina prosthesis and elucidated the biophysical mechanism of retinal stimulation. As a noninvasive blindness prosthesis, ultrasonic retina prosthesis could lead to a more effective, widely acceptable treatment for blind patients. Its real-time imaging-guided stimulation strategy with a single ultrasound array, could also benefit ultrasound neurostimulation in other diseases.

Indexed as

BlindnessRetinaVisual ProsthesisAnimalsHumansNeuronsRetinal DegenerationUltrasonic WavesUltrasonographyVision, Ocular

Identifiers

PMID38802397
PMCPMC11130148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.