ArticleNature communications2024
Cobalt-catalyzed cross-electrophile coupling of alkynyl sulfides with unactivated chlorosilanes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Deoxygenative functionalization of alcohols, ethers, and carbonyl compounds by chromium catalysis.Science advances · 2026Article
- Mg-Mediated Dual Cross-Electrophile Coupling of Propargyl and Allyl Dichlorides with Chlorosilanes: Access to Disilyl-substituted Allene and Bis(Silyl)Propenes.Angewandte Chemie (International ed. in English) · 2026Article
- Visible-Light-Mediated Metal-Free Desulfonylative Silylation for Alkenyl and Alkynylsilanes with Silacarboxylic Acids.ACS omega · 2026Article
- Harnessing Pnictogen and Chalcogen Bonding for Cross-Electrophile C-POrganic letters · 2026Article
- A DMAP-enabled strategy for C(spNature communications · 2025Article
- Catalytic Reactions Involving the Oxidative Addition of Si─Halogen and Si─Pseudohalogen Bonds as a Key Step.Chemistry, an Asian journal · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Herein, we disclose a highly efficient cobalt-catalyzed cross-electrophile alkynylation of a broad range of unactivated chlorosilanes with alkynyl sulfides as a stable and practical alkynyl electrophiles. Strategically, employing easily synthesized alkynyl sulfides as alkynyl precursors allows access to various alkynylsilanes in good to excellent yields. Notably, this method avoids the utilization of strong bases, noble metal catalysts, high temperature and forcing reaction conditions, thus presenting apparent advantages, such as broad substrate scope (72 examples, up to 97% yield), high Csp-S chemo-selectivity and excellent functional group compatibility (Ar-X, X = Cl, Br, I, OTf, OTs). Moreover, the utilities of this method are also illustrated by downstream transformations and late-stage modification of structurally complex natural products and pharmaceuticals. Mechanistic studies elucidated that the cobalt catalyst initially reacted with alkynyl sulfides, and the activation of chlorosilanes occurred via an S
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Registered trials
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