Evidence map›Paper›PMID 38802354›Full record

ArticleNature communications2024

Primate retina trades single-photon detection for high-fidelity contrast encoding.

Markku Kilpeläinen, Johan Westö, Jussi Tiihonen, Anton Laihi, Daisuke Takeshita, Fred Rieke, Petri Ala-Laurila

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Markku KilpeläinenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4112-7548
Johan WestöDepartment of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.
Jussi TiihonenMolecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-0133-6126
Anton LaihiMolecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.
Daisuke TakeshitaMolecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2599-0827
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, US.
Petri Ala-LaurilaMolecular and Integrative Biosciences Research Programme, University of Helsinki, Helsinki, Finland. petri.ala-laurila@helsinki.fi.ORCID http://orcid.org/0000-0002-6139-6825

Funding

Mechanisms controlling retinal responses to natural stimuliR01EY028542 · NEI · UNIVERSITY OF WASHINGTON · PI FREDERICK M RIEKE · 2018 to 2026
$3.5M
Retinal interactions between rod and cone signalsR01EY028111 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 2017 to 2021
$1.9M
Academy of Finland (Suomen Akatemia) 296269NEI NIH HHS R01 EY028111NEI NIH HHS R01 EY028542U.S. Department of Health & Human Services | National Institutes of Health (NIH) EY 028111
6 · The paper itself

Abstract

How the spike output of the retina enables human visual perception is not fully understood. Here, we address this at the sensitivity limit of vision by correlating human visual perception with the spike outputs of primate ON and OFF parasol (magnocellular) retinal ganglion cells in tightly matching stimulus conditions. We show that human vision at its ultimate sensitivity limit depends on the spike output of the ON but not the OFF retinal pathway. Consequently, nonlinear signal processing in the retinal ON pathway precludes perceptual detection of single photons in darkness but enables quantal-resolution discrimination of differences in light intensity.

Indexed as

Photic StimulationPhotonsRetinaRetinal Ganglion CellsAdultAnimalsContrast SensitivityFemaleHumansMacaca mulattaMalePrimatesVision, OcularVisual PathwaysVisual Perception

Identifiers

PMID38802354
PMCPMC11130139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.