ArticleNature communications2024
Pixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Fisher-information limits of detector-bandwidth-efficient 3D light-field microscopy.Research square · 2026Article
- Methods, Trade-offs, and Opportunities in High-speed Optical Microscopy for Neural Voltage imaging.Nature photonics · 2026Article
- Article
- Advancing Multicolor Super-Resolution Volume Imaging: Illuminating Complex Cellular Dynamics.JACS Au · 2025Review
- Hybrid Iterating-Averaging Low Photon Budget Gabor Holographic Microscopy.ACS photonics · 2025Article
- Stable and Lead-Free Perovskite Hemispherical Photodetector for Vivid Fourier Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review of In-Pixel Gain Amplifiers and Readout Circuits for Low-Light CMOS Image Sensors.IEEE sensors reviews · 2025Article
- Pix2HDR - A Pixel-Wise Acquisition and Deep Learning-Based Synthesis Approach for High-Speed HDR Videos.IEEE transactions on pattern analysis and machine intelligence · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
High-speed wide-field fluorescence microscopy has the potential to capture biological processes with exceptional spatiotemporal resolution. However, conventional cameras suffer from low signal-to-noise ratio at high frame rates, limiting their ability to detect faint fluorescent events. Here, we introduce an image sensor where each pixel has individually programmable sampling speed and phase, so that pixels can be arranged to simultaneously sample at high speed with a high signal-to-noise ratio. In high-speed voltage imaging experiments, our image sensor significantly increases the output signal-to-noise ratio compared to a low-noise scientific CMOS camera (~2-3 folds). This signal-to-noise ratio gain enables the detection of weak neuronal action potentials and subthreshold activities missed by the standard scientific CMOS cameras. Our camera with flexible pixel exposure configurations offers versatile sampling strategies to improve signal quality in various experimental conditions.
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Registered trials
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