Evidence map›Paper›PMID 38802262›Full record

ArticleAnnals of laboratory medicine2024

Association Between Clonal Hematopoiesis of Indeterminate Potential and Brain β-Amyloid Deposition in Korean Patients With Cognitive Impairment.

Jiwon Yun, Young Chul Youn, Hye Ryoun Kim

Abstract read
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In one paragraph

Article in Annals of laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiwon YunDepartment of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-6306-3944
Young Chul YounDepartment of Neurology, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2742-1759
Hye Ryoun KimDepartment of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9229-9665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few studies have focused on the association between clonal hematopoiesis of indeterminate potential (CHIP) and β-amyloid (Aβ) deposition in the brain, which causes Alzheimer's disease. We aimed to investigate the potential role of CHIP in brain Aβ deposition in Korean patients. We enrolled 58 Korean patients over 50 yrs of age with cognitive impairment who underwent brain Aβ positron emission tomography. We explored CHIP in their peripheral blood using deep-targeted next-generation sequencing. Irrespective of the presence or absence of brain Aβ deposition, mutations in

Indexed as

Amyloid beta-PeptidesBrainClonal HematopoiesisCognitive DysfunctionDNA (Cytosine-5-)-MethyltransferasesAgedAged, 80 and overAlzheimer DiseaseDNA Methyltransferase 3AEast Asian PeopleFemaleHigh-Throughput Nucleotide SequencingHumansLogistic ModelsMaleMiddle AgedAmyloid beta-PeptidesDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanAlzheimer’s diseaseClonal hematopoiesis of indeterminate potentialNext-generation sequencingPositron emission tomographyβ-Amyloid protein

Identifiers

PMID38802262
PMCPMC11375198

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.