Evidence map›Paper›PMID 38802243›Full record

ArticleInjury prevention : journal of the International Society for Child and Adolescent Injury Prevention2025

Comparison of different definitions of traumatic brain injury: implications for cohort characteristics and survival in women, Philadelphia, USA.

Bernadette A D'Alonzo, Abigail C Bretzin, Andrea Lc Schneider, Rebecca B Morse, Silvia P Canelón, Douglas J Wiebe, Mary Regina Boland

Abstract readComparative Study
In one paragraph

Article in Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Comparison of US TBI-related emergency department visits from two data sources: NEISS-AIP and HCUP-NEDS.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bernadette A D'AlonzoDepartment of Biostatistics Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA dalonzob@pennmedicine.upenn.edu.ORCID 0000-0002-3760-2158
Abigail C BretzinDepartment of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3730-2849
Andrea Lc SchneiderDepartment of Biostatistics Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-0026-5052
Rebecca B MorseDepartment of Biostatistics Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Silvia P CanelónDepartment of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1709-1394
Douglas J WiebeDepartment of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6434-8693
Mary Regina BolandDepartment of Mathematics, Saint Vincent College, Latrobe, Pennsylvania, USA.ORCID 0000-0001-8576-6408

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
BRIAN INJURY TRAINING GRANTT32NS043126 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith · 2003 to 2026
$5.9M
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersK23NS123340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider · 2022 to 2026
$1.1M
NCATS NIH HHS UL1 TR001878NCIPC CDC HHS R49 CE003083NINDS NIH HHS K23 NS123340NINDS NIH HHS T32 NS043126
6 · The paper itself

Abstract

backgroundTraumatic brain injury (TBI) is an acute injury that is understudied in civilian cohorts, especially among women, as TBI has historically been considered to be largely a condition of athletes and military service people. Both the Centres for Disease Control and Prevention (CDC) and Department of Defense (DOD)/Veterans Affairs (VA) have developed case definitions to identify patients with TBI from medical records; however, their definitions differ. We sought to re-examine these definitions to construct an expansive and more inclusive definition among a cohort of women with TBI.

methodsIn this study, we use electronic health records (EHR) from a single healthcare system to study the impact of using different case definitions to identify patients with TBI. Specifically, we identified adult female patients with TBI using the CDC definition, DOD/VA definition and a combined and expanded definition herein called the Penn definition.

resultsWe identified 4446 adult-female TBI patients meeting the CDC definition, 3619 meeting the DOD/VA definition, and together, 6432 meeting our expanded Penn definition that includes the CDC ad DOD/VA definitions.

conclusionsUsing the expanded definition identified almost two times as many patients, enabling investigations to more fully characterise these patients and related outcomes. Our expanded TBI case definition is available to other researchers interested in employing EHRs to investigate TBI.

Indexed as

Brain Injuries, TraumaticAdultCenters for Disease Control and Prevention, U.S.Cohort StudiesElectronic Health RecordsFemaleHumansMiddle AgedPhiladelphiaUnited StatesCohort StudyEpidemiologyStandardsTraumatic Brain Injury

Identifiers

PMID38802243
PMCPMC12377615

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.