Evidence map›Paper›PMID 38801906›Full record

ArticleChemosphere2024

Evaluation of 14 PFAS for permeability and organic anion transporter interactions: Implications for renal clearance in humans.

Sangwoo Ryu, Emi Yamaguchi, Seyed Mohamad Sadegh Modaresi, Juliana Agudelo, Chester Costales, Mark A West, Fabian Fischer, Angela L Slitt

Erratum issuedAbstract read
In one paragraph

Article in Chemosphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  18. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sangwoo RyuDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, United States; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Pfizer Inc., Groton, CT, 06340, United States.
Emi YamaguchiPharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Pfizer Inc., Groton, CT, 06340, United States.
Seyed Mohamad Sadegh ModaresiDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, United States.
Juliana AgudeloDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, United States.
Chester CostalesPharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Pfizer Inc., Groton, CT, 06340, United States.
Mark A WestPharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Pfizer Inc., Groton, CT, 06340, United States.
Fabian FischerDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, United States; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, United States. Electronic address: fabian.fischer@uri.edu.
Angela L SlittDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, 02881, United States. Electronic address: aslitt@uri.edu.

Funding

Sources, Transport, Exposure & Effects of PFAS (STEEP) Center - RENEWALP42ES027706 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI Rainer Lohmann · 2017 to 2026
$18.9M
NIEHS NIH HHS P42 ES027706
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) encompass a diverse group of synthetic fluorinated chemicals known to elicit adverse health effects in animals and humans. However, only a few studies investigated the mechanisms underlying clearance of PFAS. Herein, the relevance of human renal transporters and permeability to clearance and bioaccumulation for 14 PFAS containing three to eleven perfluorinated carbon atoms (η

Indexed as

FluorocarbonsKidneyOrganic Anion TransportersAnimalsBiological TransportDogsEnvironmental PollutantsHEK293 CellsHumansMadin Darby Canine Kidney CellsPermeabilityEnvironmental PollutantsFluorocarbonsOrganic Anion TransportersIon transportersPermeabilityPFASRenal clearance

Identifiers

PMID38801906
PMCPMC11774580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.